Translation of Pharmacogenetics into Clinically Relevant Testing Modalities

Pharmacogenetics (PGx) relies on the genetic makeup of an individual to predict drug response and efficacy, as well as potential adverse drug events. Significant advances in PGx research have been made since inherited differences in response to such drugs as isoniazid and succinylcholine were explor...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2007-10, Vol.82 (4), p.373-376
Hauptverfasser:	Baudhuin, L M, Langman, L J, O'Kane, D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - adverse effects Anticoagulants - pharmacokinetics Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Cytochrome P-450 CYP2C9 Drug Therapy Drug-Related Side Effects and Adverse Reactions Genetic Testing - economics Genetic Testing - legislation & jurisprudence Genotype Government Regulation Humans Insurance, Health, Reimbursement Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Patient Selection Pharmacogenetics - economics Pharmacogenetics - legislation & jurisprudence Phenotype Physician's Role Polymorphism, Genetic Reagent Kits, Diagnostic Reproducibility of Results Risk Assessment Vitamin K Epoxide Reductases Warfarin - adverse effects Warfarin - pharmacokinetics
Online-Zugang:	Volltext
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