The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis

The serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), has been reported to inhibit tumor necrosis factor-alpha (TNF) induced apoptosis. In order to begin to understand the molecular basis for this protection, we have investigated the importance of a structural dom...

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Veröffentlicht in:	Cell death and differentiation 1998-02, Vol.5 (2), p.163-171
Hauptverfasser:	Dickinson, J L, Norris, B J, Jensen, P H, Antalis, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Conserved Sequence DNA Primers Gene Expression Regulation, Neoplastic HeLa Cells Humans Molecular Sequence Data Multigene Family - physiology Mutagenesis - physiology Plasminogen Activator Inhibitor 2 - analysis Plasminogen Activator Inhibitor 2 - chemistry Plasminogen Activator Inhibitor 2 - genetics Protein Structure, Tertiary Sequence Homology, Amino Acid Serpins - analysis Serpins - chemistry Serpins - genetics Transfection Tumor Necrosis Factor-alpha - pharmacology
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