Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K ATP channels

We have investigated the effects of the sulphonylurea, glimepiride, currently used to treat type 2 diabetes, on ATP‐sensitive K + (K ATP ) currents of rat cardiac myocytes and on their cloned constituents Kir6.2 and SUR2A expressed in HEK 293 cells. Glimepiride blocked pinacidil‐activated whole‐cell...

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Veröffentlicht in:	British journal of pharmacology 2009-02, Vol.136 (5), p.746-752
Hauptverfasser:	Lawrence, C L, Rainbow, R D, Davies, N W, Standen, N B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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