Molecular impact of MinK on the enantiospecific block of I Ks by chromanols

Slowly activating I Ks (KCNQ1/MinK) channels were expressed in Xenopous oocytes and their sensitivity to chromanols was compared to homomeric KCNQ1 channels. To elucidate the contribution of the β‐subunit MinK on chromanol block, a formerly described chromanol HMR 1556 and its enantiomer S5557 were...

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Veröffentlicht in:	British journal of pharmacology 2009-01, Vol.131 (8), p.1503-1506
Hauptverfasser:	Lerche, C, Seebohm, G, Wagner, C I, Scherer, C R, Dehmelt, L, Abitbol, I, Gerlach, U, Brendel, J, Attali, B, Busch, A E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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