The effect of Gi‐protein inactivation on basal, and β 1 ‐ and β 2 AR‐stimulated contraction of myocytes from transgenic mice overexpressing the β 2 ‐adrenoceptor

The atria and ventricles of transgenic mice (TGβ 2 ) with cardiac overexpression of the human β 2 ‐adrenoceptor (β 2 AR) were initially reported to show maximum contractility in the absence of β‐AR stimulation. However, we have previously observed a different phenotype in these mice, with myocytes s...

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Veröffentlicht in:	British journal of pharmacology 2009-01, Vol.131 (3), p.594-600
Hauptverfasser:	Gong, Haibin, Adamson, Dawn L, Ranu, Hardeep K, Koch, Walter J, Heubach, Jürgen F, Ravens, Ursula, Zolk, Oliver, Harding, Sian E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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