Methyl p‐hydroxybenzoate (E‐218) a preservative for drugs and food is an activator of the ryanodine receptor Ca 2+ release channel
Haloperidol is a drug used in the management of several psychotic disorders and its use has been linked to Neuroleptic Malignant Syndrome. In the present study we have investigated the effect of a commercial preparation of haloperidol, Serenase, on skeletal muscle sarcoplasmic reticulum. Addition of...
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| Veröffentlicht in: | British journal of pharmacology 2009-01, Vol.131 (2), p.335-341 |
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| creator | Cavagna, Dario Zorzato, Francesco Babini, Elena Prestipino, Gianfranco Treves, Susan |
| description | Haloperidol is a drug used in the management of several psychotic disorders and its use has been linked to Neuroleptic Malignant Syndrome. In the present study we have investigated the effect of a commercial preparation of haloperidol, Serenase, on skeletal muscle sarcoplasmic reticulum.
Addition of Serenase to isolated terminal cisternae caused a rapid release of calcium. We tested whether the active Ca
2+
‐releasing substance was haloperidol or another compound present in the preparation.
Our results show that methyl p‐hydroxybenzoate, one of the preservatives and a commonly used anti‐microbial agent (E‐218) is an activator of Ca
2+
release (E.C.50=2.0 m
M
), mediated by a ruthenium red‐sensitive Ca
2+
release channel present in skeletal muscle terminal cisternae.
British Journal of Pharmacology
(2000)
131
, 335–341; doi:
10.1038/sj.bjp.0703571 |
| doi_str_mv | 10.1038/sj.bjp.0703571 |
| format | Article |
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Addition of Serenase to isolated terminal cisternae caused a rapid release of calcium. We tested whether the active Ca
2+
‐releasing substance was haloperidol or another compound present in the preparation.
Our results show that methyl p‐hydroxybenzoate, one of the preservatives and a commonly used anti‐microbial agent (E‐218) is an activator of Ca
2+
release (E.C.50=2.0 m
M
), mediated by a ruthenium red‐sensitive Ca
2+
release channel present in skeletal muscle terminal cisternae.
British Journal of Pharmacology
(2000)
131
, 335–341; doi:
10.1038/sj.bjp.0703571</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0703571</identifier><language>eng</language><ispartof>British journal of pharmacology, 2009-01, Vol.131 (2), p.335-341</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c841-727af5948cc75f5194a6c377b6ca65f7cee07f8348c972f20098d73d204b9eea3</citedby><cites>FETCH-LOGICAL-c841-727af5948cc75f5194a6c377b6ca65f7cee07f8348c972f20098d73d204b9eea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Cavagna, Dario</creatorcontrib><creatorcontrib>Zorzato, Francesco</creatorcontrib><creatorcontrib>Babini, Elena</creatorcontrib><creatorcontrib>Prestipino, Gianfranco</creatorcontrib><creatorcontrib>Treves, Susan</creatorcontrib><title>Methyl p‐hydroxybenzoate (E‐218) a preservative for drugs and food is an activator of the ryanodine receptor Ca 2+ release channel</title><title>British journal of pharmacology</title><description>Haloperidol is a drug used in the management of several psychotic disorders and its use has been linked to Neuroleptic Malignant Syndrome. In the present study we have investigated the effect of a commercial preparation of haloperidol, Serenase, on skeletal muscle sarcoplasmic reticulum.
Addition of Serenase to isolated terminal cisternae caused a rapid release of calcium. We tested whether the active Ca
2+
‐releasing substance was haloperidol or another compound present in the preparation.
Our results show that methyl p‐hydroxybenzoate, one of the preservatives and a commonly used anti‐microbial agent (E‐218) is an activator of Ca
2+
release (E.C.50=2.0 m
M
), mediated by a ruthenium red‐sensitive Ca
2+
release channel present in skeletal muscle terminal cisternae.
British Journal of Pharmacology
(2000)
131
, 335–341; doi:
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Addition of Serenase to isolated terminal cisternae caused a rapid release of calcium. We tested whether the active Ca
2+
‐releasing substance was haloperidol or another compound present in the preparation.
Our results show that methyl p‐hydroxybenzoate, one of the preservatives and a commonly used anti‐microbial agent (E‐218) is an activator of Ca
2+
release (E.C.50=2.0 m
M
), mediated by a ruthenium red‐sensitive Ca
2+
release channel present in skeletal muscle terminal cisternae.
British Journal of Pharmacology
(2000)
131
, 335–341; doi:
10.1038/sj.bjp.0703571</abstract><doi>10.1038/sj.bjp.0703571</doi><tpages>7</tpages></addata></record> |
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| source | Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| title | Methyl p‐hydroxybenzoate (E‐218) a preservative for drugs and food is an activator of the ryanodine receptor Ca 2+ release channel |
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