Pharmacokinetic‐pharmacodynamic modelling of the anti‐lipolytic and anti‐ketotic effects of the adenosine A 1 ‐receptor agonist N 6 ‐(p‐sulphophenyl)adenosine in rats

The purpose of this study was to develop and validate an integrated pharmacokinetic‐pharmacodynamic model for the anti‐lipolytic effects of the adenosine A 1 ‐receptor agonist N 6 ‐(p‐sulphophenyl)adenosine (SPA). Tissue selectivity of SPA was investigated by quantification of haemodynamic and anti‐...

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Veröffentlicht in:	British journal of pharmacology 2009-02, Vol.122 (3), p.525-533
Hauptverfasser:	Van Schaick, E. A., de Greef, H. J. M. M., Langemeijer, M. W. E., Sheehan, M. J., IJzerman, A. P., Danhof, M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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