Mammalian signaling circuits from bacterial parts

The ability to engineer synthetic signaling networks has proven challenging for synthetic biology. A breakthrough design strategy shows that bacterial two-component-system-derived parts can be grafted into mammalian cells to create programmable phosphorylation circuitry.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2020-02, Vol.16 (2), p.110-111
Hauptverfasser:	Yang, Xiaoyu, Her, John, Bashor, Caleb J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/360 631/92/552 Animals Bacteria Biochemical Engineering Biochemistry Biochemistry & Molecular Biology Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Circuits E coli Engineering Gene Regulatory Networks Kinases Life Sciences & Biomedicine Ligands Lipids Mammalian cells Mammals News & Views news-and-views Nitrates Phosphorylation Proteins Science & Technology Sensors Signal Transduction Signaling Synthetic biology
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Beschreibung
Zusammenfassung:	The ability to engineer synthetic signaling networks has proven challenging for synthetic biology. A breakthrough design strategy shows that bacterial two-component-system-derived parts can be grafted into mammalian cells to create programmable phosphorylation circuitry.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/s41589-019-0436-x