Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronar...

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Veröffentlicht in:Nature communications 2020-04, Vol.11 (1), p.1770-1770, Article 1770
Hauptverfasser: van de Vegte, Yordi J., Said, M. Abdullah, Rienstra, Michiel, van der Harst, Pim, Verweij, Niek
Format: Artikel
Sprache:eng
Schlagworte:
45/43
631/208/1515
631/208/205/2138
692/308/174
692/4019/592/75/593/15
Adult
Aged
Behavior
Body Mass Index
Body size
Cardiovascular disease
Cardiovascular diseases
Coronary artery
Coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - etiology
Coronary vessels
Education
Epidemiology
Female
Genome-Wide Association Study
Genomes
Health risk assessment
Health risks
Heart diseases
Humanities and Social Sciences
Humans
Leisure
Male
Mendelian Randomization Analysis
Mental Disorders - complications
Mental Disorders - genetics
Middle Aged
multidisciplinary
Multidisciplinary Sciences
Randomization
Risk analysis
Risk Factors
Science
Science & Technology
Science & Technology - Other Topics
Science (multidisciplinary)
Sedentary Behavior
Television
United Kingdom - epidemiology
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Beschreibung
Zusammenfassung:Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci ( P  
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-020-15553-w