Inhibition of in vitro Autosensitization by a Thymic Humoral Factor

WE have recently reported 1 that mouse lymphoid cells sensitized in vitro , according to the method of Ginsburg 2 , against either syngeneic tumour cells or syngeneic fibroblasts could mediate specific killing when tested in the microcytotoxicity assay devised by Takasugi and Klein 3 . We also found...

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Veröffentlicht in:	Nature. New biology (London) 1973-10, Vol.245 (147), p.253-255
Hauptverfasser:	TRAININ, NATHAN, CARNAUD, CLAUDE, ILFELD, DAVID
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies Autoantigens Biomedical and Life Sciences Cells, Cultured Cytotoxicity Tests, Immunologic Fibroblasts Immunity, Cellular letters-to-editor Life Sciences Mice Mice, Inbred C57BL Neoplasms, Experimental - immunology Spleen - immunology Thymectomy Thymus Gland - immunology
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creator	TRAININ, NATHAN CARNAUD, CLAUDE ILFELD, DAVID
description	WE have recently reported 1 that mouse lymphoid cells sensitized in vitro , according to the method of Ginsburg 2 , against either syngeneic tumour cells or syngeneic fibroblasts could mediate specific killing when tested in the microcytotoxicity assay devised by Takasugi and Klein 3 . We also found that the presence of a thymic humoral factor (THF) during in vitro sensitization against syngeneic tumour cells markedly increased lymphoid competence to destroy their target cells (C. C., D. I., I. Brook, and N. T., unpublished). It was therefore of interest to test whether THF would also affect autosensitization of spleen cells cultured on syngeneic fibroblast monolayers.
doi_str_mv	10.1038/newbio245253a0
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We also found that the presence of a thymic humoral factor (THF) during in vitro sensitization against syngeneic tumour cells markedly increased lymphoid competence to destroy their target cells (C. C., D. I., I. Brook, and N. T., unpublished). It was therefore of interest to test whether THF would also affect autosensitization of spleen cells cultured on syngeneic fibroblast monolayers.</description><identifier>ISSN: 0090-0028</identifier><identifier>EISSN: 2058-1092</identifier><identifier>DOI: 10.1038/newbio245253a0</identifier><identifier>PMID: 4518370</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Autoantibodies ; Autoantigens ; Biomedical and Life Sciences ; Cells, Cultured ; Cytotoxicity Tests, Immunologic ; Fibroblasts ; Immunity, Cellular ; letters-to-editor ; Life Sciences ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental - immunology ; Spleen - immunology ; Thymectomy ; Thymus Gland - immunology</subject><ispartof>Nature. 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It was therefore of interest to test whether THF would also affect autosensitization of spleen cells cultured on syngeneic fibroblast monolayers.</description><subject>Animals</subject><subject>Autoantibodies</subject><subject>Autoantigens</subject><subject>Biomedical and Life Sciences</subject><subject>Cells, Cultured</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Fibroblasts</subject><subject>Immunity, Cellular</subject><subject>letters-to-editor</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Spleen - immunology</subject><subject>Thymectomy</subject><subject>Thymus Gland - immunology</subject><issn>0090-0028</issn><issn>2058-1092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD9PwzAUxC0EKqWwsiH5C6R9_pc4Y1UBrVSJpcyR49jUVRNXdgIqnx5DKyQGpjf83p3uDqF7AlMCTM4681E7T7mggim4QGMKQmYESnqJxgAlZABUXqObGHcAjPCCjtCICyJZAWO0WHVbV7ve-Q57i12H310fPJ4PvY-mi4l8qh9aH7HCm-2xdRovh9YHtcdPSvc-3KIrq_bR3J3vBL0-PW4Wy2z98rxazNeZZoRAJnMqS1sqwTktFLVaCsUM05xqqXOaUlpRW8p4I_JUheaSNIxZUxekUaUgbIKmJ18dfIzB2OoQXKvCsSJQfY9R_R0jCR5OgsNQt6b5fT-3T3x24jGR7s2EaueH0KUO_zl-Ad7fatQ</recordid><startdate>19731024</startdate><enddate>19731024</enddate><creator>TRAININ, NATHAN</creator><creator>CARNAUD, CLAUDE</creator><creator>ILFELD, DAVID</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19731024</creationdate><title>Inhibition of in vitro Autosensitization by a Thymic Humoral Factor</title><author>TRAININ, NATHAN ; CARNAUD, CLAUDE ; ILFELD, DAVID</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3110-86289f9a54427a2fc85a3e3c42c8c62028f5bf234d563a02681d33feb71da9513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Autoantibodies</topic><topic>Autoantigens</topic><topic>Biomedical and Life Sciences</topic><topic>Cells, Cultured</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Fibroblasts</topic><topic>Immunity, Cellular</topic><topic>letters-to-editor</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Spleen - immunology</topic><topic>Thymectomy</topic><topic>Thymus Gland - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>TRAININ, NATHAN</creatorcontrib><creatorcontrib>CARNAUD, CLAUDE</creatorcontrib><creatorcontrib>ILFELD, DAVID</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nature. 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subjects	Animals Autoantibodies Autoantigens Biomedical and Life Sciences Cells, Cultured Cytotoxicity Tests, Immunologic Fibroblasts Immunity, Cellular letters-to-editor Life Sciences Mice Mice, Inbred C57BL Neoplasms, Experimental - immunology Spleen - immunology Thymectomy Thymus Gland - immunology
title	Inhibition of in vitro Autosensitization by a Thymic Humoral Factor
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