The Translation of Scale in Fermentation Processes: The Impact of Computer Process Control
Many of the physical and chemical parameters which influence the behavior of a microorganism are changed as the scale of operation is changed. A description is given of how the most important of these effect process performance. As well as opening up new doors for novel process control techniques, t...
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| Veröffentlicht in: | Bio/Technology 1984-10, Vol.2 (10), p.875-883 |
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| container_title | Bio/Technology |
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| creator | Buckland, B. C |
| description | Many of the physical and chemical parameters which influence the behavior of a microorganism are changed as the scale of operation is changed. A description is given of how the most important of these effect process performance. As well as opening up new doors for novel process control techniques, the introduction of computer process control and data acquisition have had a positive impact on all process development activities. Experimental batches in a pilot plant can now be run with greater precision than previously possible and a complete record is available of every event, both planned and unplanned, which occurs during the fermentation cycle. |
| doi_str_mv | 10.1038/nbt1084-875 |
| format | Article |
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C</creator><general>Nature Publishing Group US</general><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19841001</creationdate><title>The Translation of Scale in Fermentation Processes: The Impact of Computer Process Control</title><author>Buckland, B. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-6c0af6c6bbda8ac3aa63805ec1253fc72ebaba1c9aeb43e60a8eb1c08cdcc2613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>09 BIOMASS FUELS</topic><topic>090222 - Alcohol Fuels- Preparation from Wastes or Biomass- (1976-1989)</topic><topic>140504 - Solar Energy Conversion- Biomass Production & Conversion- (-1989)</topic><topic>Agriculture</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>BIOCONVERSION</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>BIOREACTORS</topic><topic>Biotechnology</topic><topic>CARBON COMPOUNDS</topic><topic>CARBON DIOXIDE</topic><topic>CARBON OXIDES</topic><topic>CHALCOGENIDES</topic><topic>COMPUTERIZED CONTROL SYSTEMS</topic><topic>COMPUTERS</topic><topic>CONTROL</topic><topic>CONTROL SYSTEMS</topic><topic>CULTURE MEDIA</topic><topic>DATA ACQUISITION</topic><topic>ELEMENTS</topic><topic>ENERGY TRANSFER</topic><topic>FERMENTATION</topic><topic>HEAT TRANSFER</topic><topic>KINETICS</topic><topic>Life Sciences</topic><topic>MICROORGANISMS</topic><topic>MIXING</topic><topic>MORPHOLOGICAL CHANGES</topic><topic>NONMETALS</topic><topic>OXIDES</topic><topic>OXYGEN</topic><topic>OXYGEN COMPOUNDS</topic><topic>PH VALUE</topic><topic>PROCESS CONTROL</topic><topic>REACTION KINETICS</topic><topic>review-article</topic><topic>SCALING LAWS</topic><topic>STERILIZATION</topic><topic>TEMPERATURE EFFECTS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buckland, B. 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C</au><aucorp>Merck Sharp and Dohme Research Lab., Rahway, NJ</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Translation of Scale in Fermentation Processes: The Impact of Computer Process Control</atitle><jtitle>Bio/Technology</jtitle><stitle>Nat Biotechnol</stitle><date>1984-10-01</date><risdate>1984</risdate><volume>2</volume><issue>10</issue><spage>875</spage><epage>883</epage><pages>875-883</pages><issn>0733-222X</issn><issn>1087-0156</issn><eissn>2331-3684</eissn><eissn>1546-1696</eissn><abstract>Many of the physical and chemical parameters which influence the behavior of a microorganism are changed as the scale of operation is changed. A description is given of how the most important of these effect process performance. As well as opening up new doors for novel process control techniques, the introduction of computer process control and data acquisition have had a positive impact on all process development activities. Experimental batches in a pilot plant can now be run with greater precision than previously possible and a complete record is available of every event, both planned and unplanned, which occurs during the fermentation cycle.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><doi>10.1038/nbt1084-875</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0733-222X |
| ispartof | Bio/Technology, 1984-10, Vol.2 (10), p.875-883 |
| issn | 0733-222X 1087-0156 2331-3684 1546-1696 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_nbt1084_875 |
| source | Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | 09 BIOMASS FUELS 090222 - Alcohol Fuels- Preparation from Wastes or Biomass- (1976-1989) 140504 - Solar Energy Conversion- Biomass Production & Conversion- (-1989) Agriculture BIOCHEMICAL REACTION KINETICS BIOCONVERSION Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine BIOREACTORS Biotechnology CARBON COMPOUNDS CARBON DIOXIDE CARBON OXIDES CHALCOGENIDES COMPUTERIZED CONTROL SYSTEMS COMPUTERS CONTROL CONTROL SYSTEMS CULTURE MEDIA DATA ACQUISITION ELEMENTS ENERGY TRANSFER FERMENTATION HEAT TRANSFER KINETICS Life Sciences MICROORGANISMS MIXING MORPHOLOGICAL CHANGES NONMETALS OXIDES OXYGEN OXYGEN COMPOUNDS PH VALUE PROCESS CONTROL REACTION KINETICS review-article SCALING LAWS STERILIZATION TEMPERATURE EFFECTS |
| title | The Translation of Scale in Fermentation Processes: The Impact of Computer Process Control |
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