STEM Footprints and Bound Mass Distributions for DNA Control Proteins
We review a current methodology which analyzes quantitative scattering data from Scanning Transmission Electron Microscopy to establish footprints—positions of DNA-binding proteins on cloned genes—and mass distributions for the bound protein. Recognition by computer of the DNA path and the extent of...
Gespeichert in:
| Veröffentlicht in: | Bio/Technology 1985-06, Vol.3 (6), p.549-553 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 553 |
|---|---|
| container_issue | 6 |
| container_start_page | 549 |
| container_title | Bio/Technology |
| container_volume | 3 |
| creator | Hough, Paul V. C Mastrangelo, Iris A Wall, Joseph S Hainfeld, James F Wilson, Van G Ryder, Kevin Tegtmeyer, Peter |
| description | We review a current methodology which analyzes quantitative scattering data from Scanning Transmission Electron Microscopy to establish footprints—positions of DNA-binding proteins on cloned genes—and mass distributions for the bound protein. Recognition by computer of the DNA path and the extent of the bound protein leads to an analysis rate which is high for image-based data. The methods have been applied in the study of eukaryotic transcription initiation and T antigen interaction with the SV40 control region. |
| doi_str_mv | 10.1038/nbt0685-549 |
| format | Article |
| fullrecord | <record><control><sourceid>nature_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1038_nbt0685_549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>nbt0685-549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c254t-4ef0c014955237e21645fa1b0b179eda1d84da05e54a6a0303309c3738a6d4b63</originalsourceid><addsrcrecordid>eNp1kLFOwzAURS0EEqUw8QNmhsCzn-0kY2lTQGoBiSKxRU7ioFTFRrYz9O9J1QqxsLy7HF3ddwi5ZHDLALM7W0VQmUykyI_IiCOyBFUmjskIUsSEc_5xSs5CWAOIVHExIsXbqljSuXPx23c2BqptQ-9dP9ylDoHOuhB9V_WxczbQ1nk6e57QqbPRuw199S6azoZzctLqTTAXhxyT93mxmj4mi5eHp-lkkdRcipgI00INTORSckwNZ0rIVrMKKpbmptGsyUSjQRoptNKAgAh5jSlmWjWiUjgm1_ve2rsQvGnLYfWX9tuSQbkzUB4MlIOBgb7Z02H326fx5dr13g4D_8Gv9rjVsffmt_qPVPwBRcVnaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>STEM Footprints and Bound Mass Distributions for DNA Control Proteins</title><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Hough, Paul V. C ; Mastrangelo, Iris A ; Wall, Joseph S ; Hainfeld, James F ; Wilson, Van G ; Ryder, Kevin ; Tegtmeyer, Peter</creator><creatorcontrib>Hough, Paul V. C ; Mastrangelo, Iris A ; Wall, Joseph S ; Hainfeld, James F ; Wilson, Van G ; Ryder, Kevin ; Tegtmeyer, Peter</creatorcontrib><description>We review a current methodology which analyzes quantitative scattering data from Scanning Transmission Electron Microscopy to establish footprints—positions of DNA-binding proteins on cloned genes—and mass distributions for the bound protein. Recognition by computer of the DNA path and the extent of the bound protein leads to an analysis rate which is high for image-based data. The methods have been applied in the study of eukaryotic transcription initiation and T antigen interaction with the SV40 control region.</description><identifier>ISSN: 0733-222X</identifier><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 2331-3684</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt0685-549</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Bioinformatics ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Life Sciences ; review-article</subject><ispartof>Bio/Technology, 1985-06, Vol.3 (6), p.549-553</ispartof><rights>Nature Publishing Company 1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c254t-4ef0c014955237e21645fa1b0b179eda1d84da05e54a6a0303309c3738a6d4b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids></links><search><creatorcontrib>Hough, Paul V. C</creatorcontrib><creatorcontrib>Mastrangelo, Iris A</creatorcontrib><creatorcontrib>Wall, Joseph S</creatorcontrib><creatorcontrib>Hainfeld, James F</creatorcontrib><creatorcontrib>Wilson, Van G</creatorcontrib><creatorcontrib>Ryder, Kevin</creatorcontrib><creatorcontrib>Tegtmeyer, Peter</creatorcontrib><title>STEM Footprints and Bound Mass Distributions for DNA Control Proteins</title><title>Bio/Technology</title><addtitle>Nat Biotechnol</addtitle><description>We review a current methodology which analyzes quantitative scattering data from Scanning Transmission Electron Microscopy to establish footprints—positions of DNA-binding proteins on cloned genes—and mass distributions for the bound protein. Recognition by computer of the DNA path and the extent of the bound protein leads to an analysis rate which is high for image-based data. The methods have been applied in the study of eukaryotic transcription initiation and T antigen interaction with the SV40 control region.</description><subject>Agriculture</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Life Sciences</subject><subject>review-article</subject><issn>0733-222X</issn><issn>1087-0156</issn><issn>2331-3684</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNp1kLFOwzAURS0EEqUw8QNmhsCzn-0kY2lTQGoBiSKxRU7ioFTFRrYz9O9J1QqxsLy7HF3ddwi5ZHDLALM7W0VQmUykyI_IiCOyBFUmjskIUsSEc_5xSs5CWAOIVHExIsXbqljSuXPx23c2BqptQ-9dP9ylDoHOuhB9V_WxczbQ1nk6e57QqbPRuw199S6azoZzctLqTTAXhxyT93mxmj4mi5eHp-lkkdRcipgI00INTORSckwNZ0rIVrMKKpbmptGsyUSjQRoptNKAgAh5jSlmWjWiUjgm1_ve2rsQvGnLYfWX9tuSQbkzUB4MlIOBgb7Z02H326fx5dr13g4D_8Gv9rjVsffmt_qPVPwBRcVnaw</recordid><startdate>19850601</startdate><enddate>19850601</enddate><creator>Hough, Paul V. C</creator><creator>Mastrangelo, Iris A</creator><creator>Wall, Joseph S</creator><creator>Hainfeld, James F</creator><creator>Wilson, Van G</creator><creator>Ryder, Kevin</creator><creator>Tegtmeyer, Peter</creator><general>Nature Publishing Group US</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19850601</creationdate><title>STEM Footprints and Bound Mass Distributions for DNA Control Proteins</title><author>Hough, Paul V. C ; Mastrangelo, Iris A ; Wall, Joseph S ; Hainfeld, James F ; Wilson, Van G ; Ryder, Kevin ; Tegtmeyer, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-4ef0c014955237e21645fa1b0b179eda1d84da05e54a6a0303309c3738a6d4b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Agriculture</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Life Sciences</topic><topic>review-article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hough, Paul V. C</creatorcontrib><creatorcontrib>Mastrangelo, Iris A</creatorcontrib><creatorcontrib>Wall, Joseph S</creatorcontrib><creatorcontrib>Hainfeld, James F</creatorcontrib><creatorcontrib>Wilson, Van G</creatorcontrib><creatorcontrib>Ryder, Kevin</creatorcontrib><creatorcontrib>Tegtmeyer, Peter</creatorcontrib><collection>CrossRef</collection><jtitle>Bio/Technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hough, Paul V. C</au><au>Mastrangelo, Iris A</au><au>Wall, Joseph S</au><au>Hainfeld, James F</au><au>Wilson, Van G</au><au>Ryder, Kevin</au><au>Tegtmeyer, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STEM Footprints and Bound Mass Distributions for DNA Control Proteins</atitle><jtitle>Bio/Technology</jtitle><stitle>Nat Biotechnol</stitle><date>1985-06-01</date><risdate>1985</risdate><volume>3</volume><issue>6</issue><spage>549</spage><epage>553</epage><pages>549-553</pages><issn>0733-222X</issn><issn>1087-0156</issn><eissn>2331-3684</eissn><eissn>1546-1696</eissn><abstract>We review a current methodology which analyzes quantitative scattering data from Scanning Transmission Electron Microscopy to establish footprints—positions of DNA-binding proteins on cloned genes—and mass distributions for the bound protein. Recognition by computer of the DNA path and the extent of the bound protein leads to an analysis rate which is high for image-based data. The methods have been applied in the study of eukaryotic transcription initiation and T antigen interaction with the SV40 control region.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><doi>10.1038/nbt0685-549</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0733-222X |
| ispartof | Bio/Technology, 1985-06, Vol.3 (6), p.549-553 |
| issn | 0733-222X 1087-0156 2331-3684 1546-1696 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_nbt0685_549 |
| source | Nature; Alma/SFX Local Collection |
| subjects | Agriculture Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Life Sciences review-article |
| title | STEM Footprints and Bound Mass Distributions for DNA Control Proteins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T10%3A55%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nature_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=STEM%20Footprints%20and%20Bound%20Mass%20Distributions%20for%20DNA%20Control%20Proteins&rft.jtitle=Bio/Technology&rft.au=Hough,%20Paul%20V.%20C&rft.date=1985-06-01&rft.volume=3&rft.issue=6&rft.spage=549&rft.epage=553&rft.pages=549-553&rft.issn=0733-222X&rft.eissn=2331-3684&rft_id=info:doi/10.1038/nbt0685-549&rft_dat=%3Cnature_cross%3Enbt0685-549%3C/nature_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |