FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes

The identification of fusin and other chemokine receptors as coreceptors for HIV-1 has renewed the interest in agents that may prevent viral entry. Polyanionic compounds such as dextran sulfate, curdian sulfate, and suramin act on the V3 loop of the viral envelope and may prevent its interaction wit...

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Veröffentlicht in:	Nature biotechnology 1997-04, Vol.15 (4), p.343-348
Hauptverfasser:	ONO, M, WADA, Y, WESOLOWSKI, J, WAY, J. C, ITOH, I, GILLIES, S, LAN BO CHEN, WU, Y, NEMORI, R, JINBO, Y, WANG, H, LO, K.-M, YAMAGUCHI, N, BRUNKHORST, B, OTOMO, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral drugs Biological and medical sciences Biotechnology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - virology Cell Line Chlorobenzenes - pharmacokinetics Chlorobenzenes - pharmacology Dogs Drug Resistance, Microbial - genetics Fundamental and applied biological sciences. Psychology Gene Products, env - antagonists & inhibitors Gene Products, env - physiology Genetic Variation Health. Pharmaceutical industry HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - physiology HIV Infections - prevention & control HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Humans Industrial applications and implications. Economical aspects Lymph Nodes - metabolism Male Medical sciences Membrane Fusion - drug effects Mice Mice, SCID Naphthalenes - pharmacokinetics Naphthalenes - pharmacology Peptide Fragments - drug effects Peptide Fragments - physiology Pharmacology. Drug treatments Production of active biomolecules Rats Rats, Sprague-Dawley
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