Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

Calcium–lipid electrostatic interactions are shown to amplify the tyrosine phosphorylation of CD3ε and CD3ζ in T-cell antigen receptor complex. Calcium control of T cells These authors show that Ca 2+ can regulate the ionic interaction between the T-cell receptor–CD3 complex (TCR) and anionic phosph...

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Veröffentlicht in:	Nature (London) 2013-01, Vol.493 (7430), p.111-115
Hauptverfasser:	Shi, Xiaoshan, Bi, Yunchen, Yang, Wei, Guo, Xingdong, Jiang, Yan, Wan, Chanjuan, Li, Lunyi, Bai, Yibing, Guo, Jun, Wang, Yujuan, Chen, Xiangjun, Wu, Bo, Sun, Hongbin, Liu, Wanli, Wang, Junfeng, Xu, Chenqi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1775 631/45/287 631/80/86/1999 Animals Biological and medical sciences Calcium - metabolism Calcium - pharmacology Cell Membrane - metabolism Cytoplasm - metabolism Feedback, Physiological - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humanities and Social Sciences Humans Immunobiology Jurkat Cells letter Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lymphocyte Activation - drug effects Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice multidisciplinary Phospholipids - chemistry Phospholipids - metabolism Phosphorylation - drug effects Receptor-CD3 Complex, Antigen, T-Cell - drug effects Receptor-CD3 Complex, Antigen, T-Cell - immunology Receptor-CD3 Complex, Antigen, T-Cell - metabolism Science Signal Transduction - drug effects Solvents - chemistry Solvents - metabolism Static Electricity T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Tyrosine - metabolism
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