Integrin αvβ3 Expression in Colon Carcinoma Correlates with Survival
Integrin αvβ3 is expressed by newly formed blood vessels in diseased and neoplastic tissue and can therefore be used as a marker for angiogenesis. We investigated its expression on the vasculature of 40 colon carcinomas using the anti-αvβ3-specific monoclonal antibody LM609. The average relapse-free...
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| Veröffentlicht in: | Modern pathology 2001-11, Vol.14 (11), p.1126-1132 |
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| creator | Vonlaufen, Alain Wiedle, Guido Borisch, Bettina Birrer, Stefan Luder, Peter Imhof, Beat A |
| description | Integrin αvβ3 is expressed by newly formed blood vessels in diseased and neoplastic tissue and can therefore be used as a marker for angiogenesis. We investigated its expression on the vasculature of 40 colon carcinomas using the anti-αvβ3-specific monoclonal antibody LM609. The average relapse-free interval and overall survival in patients suffering from colon carcinomas with high vascular expression of αvβ3 integrin was significantly reduced compared with that in patients with low αvβ3 integrin expressing tumor vasculature. Moreover, the expression level of αvβ3 integrin correlated with the presence of liver metastases. In conclusion, we propose vascular expression of αvβ3 integrin as a prognostic indicator for colon carcinoma. |
| doi_str_mv | 10.1038/modpathol.3880447 |
| format | Article |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Carcinoma Endothelium Laboratory Medicine Medicine Medicine & Public Health original-article Pathology Survival αvβ3 integrin |
| title | Integrin αvβ3 Expression in Colon Carcinoma Correlates with Survival |
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