Activation of protein kinase C reduces thromboxane receptors in glomeruli and mesangial cells

Activation of protein kinase C reduces thromboxane receptors in glomeruli and mesangial cells. The potential role of protein kinase C (PKC) in the modulation of thromboxane A2 (TX) receptor density was evaluated in intact glomeruli and cultured renal mesangial cells (MC) from the rat. Incubation of...

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Veröffentlicht in:	Kidney international 1993-07, Vol.44 (1), p.58-64
Hauptverfasser:	Studer, Rebecca K., Craven, Patricia A., DeRubertis, Frederick R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic Cells, Cultured Enzyme Activation - drug effects Fatty Acids, Unsaturated Female Fundamental and applied biological sciences. Psychology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Glucose - pharmacology Hydrazines - metabolism In Vitro Techniques Intracellular Signaling Peptides and Proteins Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Membrane Proteins Myristoylated Alanine-Rich C Kinase Substrate Phorbol 12,13-Dibutyrate - pharmacology Phosphorylation Protein Kinase C - metabolism Proteins - metabolism Rats Rats, Sprague-Dawley Receptors, Thromboxane - metabolism Vertebrates: urinary system
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