Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes
Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes mellitus (NIDDM). Since renal hemodynamic disturbances are important in renal injury and are exacerbated by elevated plasma amino acid concentrations in insulin-dependent di...
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| Veröffentlicht in: | Kidney international 1992-07, Vol.42 (1), p.167-173 |
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| description | Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes mellitus (NIDDM). Since renal hemodynamic disturbances are important in renal injury and are exacerbated by elevated plasma amino acid concentrations in insulin-dependent diabetes, we measured glomerular filtration rate (GFR) and renal plasma flow (RPF) after an overnight fast and during amino acid infusion in 12 patients with NIDDM and nine normal subjects. In the diabetic patients (plasma glucose 12.4 ± 0.6mmol/liter), the fasting GFR (113 ± 6 vs. 98 ± 7ml/min · 1.73m2 in normal subjects, P = 0.056) and RPF (635 ± 37 vs. 540 ± 20ml/min · 1.73m2 in normal subjects, P < 0.05) were increased. After amino acid infusion, the increase in GFR (159 ± 7 vs. 121 ± 6ml/min · 1.73m2 in normal subjects, P < 0.05) and RPF (970 ± 51 vs. 700 ± 18ml/min · 1.73m2 in normal subjects, P < 0.05) were augmented. Insulin infusion for 36 hours did not change these responses. After three weeks of insulin therapy (plasma glucose 5.9 ± 0.2mmol/ liter), the amino acid-stimulated GFR (143 ± 5ml/min · 1.73m2) and RPF (836 ± 30ml/min · 1.73m2) declined (P < 0.05), while the fasting values remained unchanged. The right kidney volume was measured by ultrasonography and found to decrease after three weeks of insulin therapy from 188 ± 12 to 165 ± 9ml/1.73m2 (P < 0.05). However, both values were greater than that in the normal subjects, 124 ± 13ml/1.73m2 (P < 0.01). Glomerular hyperfiltration and hyperperfusion became augmented during hyperaminoacidemia in our NIDDM patients. Both the augmented hemodynamic response to amino acids and renal hypertrophy regressed after three weeks of strict glycemic control. |
| doi_str_mv | 10.1038/ki.1992.274 |
| format | Article |
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Lewis</creator><creatorcontrib>Tuttle, Katherine R. ; Bruton, J. Lewis</creatorcontrib><description><![CDATA[Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes mellitus (NIDDM). Since renal hemodynamic disturbances are important in renal injury and are exacerbated by elevated plasma amino acid concentrations in insulin-dependent diabetes, we measured glomerular filtration rate (GFR) and renal plasma flow (RPF) after an overnight fast and during amino acid infusion in 12 patients with NIDDM and nine normal subjects. In the diabetic patients (plasma glucose 12.4 ± 0.6mmol/liter), the fasting GFR (113 ± 6 vs. 98 ± 7ml/min · 1.73m2 in normal subjects, P = 0.056) and RPF (635 ± 37 vs. 540 ± 20ml/min · 1.73m2 in normal subjects, P < 0.05) were increased. After amino acid infusion, the increase in GFR (159 ± 7 vs. 121 ± 6ml/min · 1.73m2 in normal subjects, P < 0.05) and RPF (970 ± 51 vs. 700 ± 18ml/min · 1.73m2 in normal subjects, P < 0.05) were augmented. Insulin infusion for 36 hours did not change these responses. After three weeks of insulin therapy (plasma glucose 5.9 ± 0.2mmol/ liter), the amino acid-stimulated GFR (143 ± 5ml/min · 1.73m2) and RPF (836 ± 30ml/min · 1.73m2) declined (P < 0.05), while the fasting values remained unchanged. The right kidney volume was measured by ultrasonography and found to decrease after three weeks of insulin therapy from 188 ± 12 to 165 ± 9ml/1.73m2 (P < 0.05). However, both values were greater than that in the normal subjects, 124 ± 13ml/1.73m2 (P < 0.01). Glomerular hyperfiltration and hyperperfusion became augmented during hyperaminoacidemia in our NIDDM patients. Both the augmented hemodynamic response to amino acids and renal hypertrophy regressed after three weeks of strict glycemic control.]]></description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1992.274</identifier><identifier>PMID: 1635346</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>MALDEN: Elsevier Inc</publisher><subject>Adult ; Albuminuria - drug therapy ; Amino Acids - pharmacology ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Nephropathies - drug therapy ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; Female ; Glomerular Filtration Rate - drug effects ; Hormones. Endocrine system ; Humans ; Hypertrophy ; Insulin - therapeutic use ; Kidney - pathology ; Life Sciences & Biomedicine ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Renal Circulation - drug effects ; Science & Technology ; Urology & Nephrology</subject><ispartof>Kidney international, 1992-07, Vol.42 (1), p.167-173</ispartof><rights>1992 International Society of Nephrology</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>29</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HY76200022</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c420t-77b9574831fb8cd145ecc05c4b9358ecbb086ca11642c5988e851c9617ba049b3</citedby><cites>FETCH-LOGICAL-c420t-77b9574831fb8cd145ecc05c4b9358ecbb086ca11642c5988e851c9617ba049b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,782,786,791,792,23939,23940,25149,27201,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5405945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1635346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuttle, Katherine R.</creatorcontrib><creatorcontrib>Bruton, J. Lewis</creatorcontrib><title>Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes</title><title>Kidney international</title><addtitle>KIDNEY INT</addtitle><addtitle>Kidney Int</addtitle><description><![CDATA[Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes mellitus (NIDDM). Since renal hemodynamic disturbances are important in renal injury and are exacerbated by elevated plasma amino acid concentrations in insulin-dependent diabetes, we measured glomerular filtration rate (GFR) and renal plasma flow (RPF) after an overnight fast and during amino acid infusion in 12 patients with NIDDM and nine normal subjects. In the diabetic patients (plasma glucose 12.4 ± 0.6mmol/liter), the fasting GFR (113 ± 6 vs. 98 ± 7ml/min · 1.73m2 in normal subjects, P = 0.056) and RPF (635 ± 37 vs. 540 ± 20ml/min · 1.73m2 in normal subjects, P < 0.05) were increased. After amino acid infusion, the increase in GFR (159 ± 7 vs. 121 ± 6ml/min · 1.73m2 in normal subjects, P < 0.05) and RPF (970 ± 51 vs. 700 ± 18ml/min · 1.73m2 in normal subjects, P < 0.05) were augmented. Insulin infusion for 36 hours did not change these responses. After three weeks of insulin therapy (plasma glucose 5.9 ± 0.2mmol/ liter), the amino acid-stimulated GFR (143 ± 5ml/min · 1.73m2) and RPF (836 ± 30ml/min · 1.73m2) declined (P < 0.05), while the fasting values remained unchanged. The right kidney volume was measured by ultrasonography and found to decrease after three weeks of insulin therapy from 188 ± 12 to 165 ± 9ml/1.73m2 (P < 0.05). However, both values were greater than that in the normal subjects, 124 ± 13ml/1.73m2 (P < 0.01). Glomerular hyperfiltration and hyperperfusion became augmented during hyperaminoacidemia in our NIDDM patients. Both the augmented hemodynamic response to amino acids and renal hypertrophy regressed after three weeks of strict glycemic control.]]></description><subject>Adult</subject><subject>Albuminuria - drug therapy</subject><subject>Amino Acids - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Nephropathies - drug therapy</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Insulin - therapeutic use</subject><subject>Kidney - pathology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Renal Circulation - drug effects</subject><subject>Science & Technology</subject><subject>Urology & Nephrology</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkr2P1DAQxSMEOpaDihrhAtGgLHYcJ055Wh0c0kk0UFBZ_phozSZ2sB1QGv52vEq4bShobHnm997Izy6KlwTvCab8_cnuSddV-6qtHxU7wipakpaxx8UOY87KilH-tHgW43eczx3FV8UVaSijdbMrft_2PeiEfI-si_NgHUpHCHJakHcogJMDOsLozeLkaHWuxMm7CCh5lAsur9qaiKQzf-llgpCCn45LtkTOu3JzLg1M4Ay4hIyVChLE58WTXg4RXmz7dfH1w-2Xw115__njp8PNfanrCqeybVXH2ppT0iuuDakZaI2ZrlVHGQetFOaNloQ0daVZxzlwRnTXkFZJXHeKXhdvV98p-B8zxCRGGzUMg3Tg5yhaijntOM3guxXUwccYoBdTsKMMiyBYnNMWJyvOaYucdqZfbbazGsFc2DXe3H-z9WXUcuiDdNrGB4zVmHU1uwz9Bcr3UVtwGh6om_O4u29tU-X3q6pM8_-nDzbJZL07-NmlLH29Sp1Mc7iITvasWm_EVgLya_y0EMQ2wNiQ_4kw3v4ziT9WR8cG</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Tuttle, Katherine R.</creator><creator>Bruton, J. Lewis</creator><general>Elsevier Inc</general><general>Wiley</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes</title><author>Tuttle, Katherine R. ; Bruton, J. Lewis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-77b9574831fb8cd145ecc05c4b9358ecbb086ca11642c5988e851c9617ba049b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Albuminuria - drug therapy</topic><topic>Amino Acids - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Nephropathies - drug therapy</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Insulin - therapeutic use</topic><topic>Kidney - pathology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Renal Circulation - drug effects</topic><topic>Science & Technology</topic><topic>Urology & Nephrology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuttle, Katherine R.</creatorcontrib><creatorcontrib>Bruton, J. Lewis</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuttle, Katherine R.</au><au>Bruton, J. Lewis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes</atitle><jtitle>Kidney international</jtitle><stitle>KIDNEY INT</stitle><addtitle>Kidney Int</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>42</volume><issue>1</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract><![CDATA[Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes mellitus (NIDDM). Since renal hemodynamic disturbances are important in renal injury and are exacerbated by elevated plasma amino acid concentrations in insulin-dependent diabetes, we measured glomerular filtration rate (GFR) and renal plasma flow (RPF) after an overnight fast and during amino acid infusion in 12 patients with NIDDM and nine normal subjects. In the diabetic patients (plasma glucose 12.4 ± 0.6mmol/liter), the fasting GFR (113 ± 6 vs. 98 ± 7ml/min · 1.73m2 in normal subjects, P = 0.056) and RPF (635 ± 37 vs. 540 ± 20ml/min · 1.73m2 in normal subjects, P < 0.05) were increased. After amino acid infusion, the increase in GFR (159 ± 7 vs. 121 ± 6ml/min · 1.73m2 in normal subjects, P < 0.05) and RPF (970 ± 51 vs. 700 ± 18ml/min · 1.73m2 in normal subjects, P < 0.05) were augmented. Insulin infusion for 36 hours did not change these responses. After three weeks of insulin therapy (plasma glucose 5.9 ± 0.2mmol/ liter), the amino acid-stimulated GFR (143 ± 5ml/min · 1.73m2) and RPF (836 ± 30ml/min · 1.73m2) declined (P < 0.05), while the fasting values remained unchanged. The right kidney volume was measured by ultrasonography and found to decrease after three weeks of insulin therapy from 188 ± 12 to 165 ± 9ml/1.73m2 (P < 0.05). However, both values were greater than that in the normal subjects, 124 ± 13ml/1.73m2 (P < 0.01). Glomerular hyperfiltration and hyperperfusion became augmented during hyperaminoacidemia in our NIDDM patients. Both the augmented hemodynamic response to amino acids and renal hypertrophy regressed after three weeks of strict glycemic control.]]></abstract><cop>MALDEN</cop><pub>Elsevier Inc</pub><pmid>1635346</pmid><doi>10.1038/ki.1992.274</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Albuminuria - drug therapy Amino Acids - pharmacology Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic Nephropathies - drug therapy Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Female Glomerular Filtration Rate - drug effects Hormones. Endocrine system Humans Hypertrophy Insulin - therapeutic use Kidney - pathology Life Sciences & Biomedicine Male Medical sciences Middle Aged Pharmacology. Drug treatments Renal Circulation - drug effects Science & Technology Urology & Nephrology |
| title | Effect of insulin therapy on renal hemodynamic response to amino acids and renal hypertrophy in non-insulin-dependent diabetes |
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