SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation: II. Structure Elucidation
Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomyci...
Gespeichert in:
| Veröffentlicht in: | Journal of antibiotics 2008-05, Vol.61 (5), p.312-317 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 317 |
|---|---|
| container_issue | 5 |
| container_start_page | 312 |
| container_title | Journal of antibiotics |
| container_volume | 61 |
| creator | Kawamura, Tatsuro Tashiro, Etsu Shindo, Kazutoshi Imoto, Masaya |
| description | Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of
Streptomyces
sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties. |
| doi_str_mv | 10.1038/ja.2008.44 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref_sprin</sourceid><recordid>TN_cdi_crossref_primary_10_1038_ja_2008_44</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1038_ja_2008_44</sourcerecordid><originalsourceid>FETCH-LOGICAL-c255t-b042ce22da5f19a7ed6e9f2c5c624e1c1b007783b0a3fd3234e03fa8ed837f3f3</originalsourceid><addsrcrecordid>eNpt0MtKw0AUBuBBFKzVjU8wa23q3NJMl7XUWihe2gruwmQuOqGZKTNJsU_hK5tQceXqwOHj_IcfgGuMhhhRfleKIUGIDxk7AT3MOU4wG41PQQ8hghPOCToHFzGWCNGMZrwHvteTFVzXjTpAb6CAT36vt3ATrHY6ES6K6iCtg_Pgmx2c-mrnG6cG8LWxztetCvbLugEUTsGV3opaqz8V23WEC_dpC1v7ELuAWRcWdIyJdaqRrX6_f8FwImu7F7X17hKcGbGN-up39sHbw2wzfUyWz_PFdLJMJEnTOikQI1ITokRq8FhkWo302BCZyhFhGktcIJRlnBZIUKMooUwjagTXitPMUEP74OZ4VwYfY9Am3wVbiXDIMcq7KvNS5F2VOWMtvj3i2CL3oUNe-ia49r__9A8PzHaT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation: II. Structure Elucidation</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kawamura, Tatsuro ; Tashiro, Etsu ; Shindo, Kazutoshi ; Imoto, Masaya</creator><creatorcontrib>Kawamura, Tatsuro ; Tashiro, Etsu ; Shindo, Kazutoshi ; Imoto, Masaya</creatorcontrib><description>Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of
Streptomyces
sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2008.44</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Life Sciences ; Medicinal Chemistry ; Microbiology ; Organic Chemistry</subject><ispartof>Journal of antibiotics, 2008-05, Vol.61 (5), p.312-317</ispartof><rights>Japan Antibiotics Research Association 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c255t-b042ce22da5f19a7ed6e9f2c5c624e1c1b007783b0a3fd3234e03fa8ed837f3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Kawamura, Tatsuro</creatorcontrib><creatorcontrib>Tashiro, Etsu</creatorcontrib><creatorcontrib>Shindo, Kazutoshi</creatorcontrib><creatorcontrib>Imoto, Masaya</creatorcontrib><title>SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation: II. Structure Elucidation</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><description>Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of
Streptomyces
sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.</description><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpt0MtKw0AUBuBBFKzVjU8wa23q3NJMl7XUWihe2gruwmQuOqGZKTNJsU_hK5tQceXqwOHj_IcfgGuMhhhRfleKIUGIDxk7AT3MOU4wG41PQQ8hghPOCToHFzGWCNGMZrwHvteTFVzXjTpAb6CAT36vt3ATrHY6ES6K6iCtg_Pgmx2c-mrnG6cG8LWxztetCvbLugEUTsGV3opaqz8V23WEC_dpC1v7ELuAWRcWdIyJdaqRrX6_f8FwImu7F7X17hKcGbGN-up39sHbw2wzfUyWz_PFdLJMJEnTOikQI1ITokRq8FhkWo302BCZyhFhGktcIJRlnBZIUKMooUwjagTXitPMUEP74OZ4VwYfY9Am3wVbiXDIMcq7KvNS5F2VOWMtvj3i2CL3oUNe-ia49r__9A8PzHaT</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Kawamura, Tatsuro</creator><creator>Tashiro, Etsu</creator><creator>Shindo, Kazutoshi</creator><creator>Imoto, Masaya</creator><general>Nature Publishing Group UK</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20080501</creationdate><title>SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation</title><author>Kawamura, Tatsuro ; Tashiro, Etsu ; Shindo, Kazutoshi ; Imoto, Masaya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-b042ce22da5f19a7ed6e9f2c5c624e1c1b007783b0a3fd3234e03fa8ed837f3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawamura, Tatsuro</creatorcontrib><creatorcontrib>Tashiro, Etsu</creatorcontrib><creatorcontrib>Shindo, Kazutoshi</creatorcontrib><creatorcontrib>Imoto, Masaya</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawamura, Tatsuro</au><au>Tashiro, Etsu</au><au>Shindo, Kazutoshi</au><au>Imoto, Masaya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation: II. Structure Elucidation</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><date>2008-05-01</date><risdate>2008</risdate><volume>61</volume><issue>5</issue><spage>312</spage><epage>317</epage><pages>312-317</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of
Streptomyces
sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/ja.2008.44</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2008-05, Vol.61 (5), p.312-317 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_ja_2008_44 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Life Sciences Medicinal Chemistry Microbiology Organic Chemistry |
| title | SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation: II. Structure Elucidation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T18%3A42%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref_sprin&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SAR%20Study%20of%20a%20Novel%20Triene-ansamycin%20Group%20Compound,%20Quinotrierixin,%20and%20Related%20Compounds,%20as%20Inhibitors%20of%20ER%20Stress-induced%20XBP1%20Activation:%20II.%20Structure%20Elucidation&rft.jtitle=Journal%20of%20antibiotics&rft.au=Kawamura,%20Tatsuro&rft.date=2008-05-01&rft.volume=61&rft.issue=5&rft.spage=312&rft.epage=317&rft.pages=312-317&rft.issn=0021-8820&rft.eissn=1881-1469&rft_id=info:doi/10.1038/ja.2008.44&rft_dat=%3Ccrossref_sprin%3E10_1038_ja_2008_44%3C/crossref_sprin%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |