A discrete population of IFN λ‐expressing BDCA3 hi dendritic cells is present in human thymus

A discrete population of IFN λ‐expressing BDCA3 hi dendritic cells is present in human thymus

Human thymus contains two major subpopulations of dendritic cells (DCs), conventional DCs (cDCs) and plasmacytoid DCs (pDCs), which are mainly involved in central tolerance and also in protecting the thymus against infections. In blood and peripheral organs cDCs include the subpopulation of BDCA3 hi...

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Veröffentlicht in:Immunology and cell biology 2015-08, Vol.93 (7), p.673-678
Hauptverfasser: Martínez, Víctor G, Canseco, Noelia M, Hidalgo, Laura, Valencia, Jaris, Entrena, Ana, Fernández‐Sevilla, Lidia M, Hernández‐López, Carmen, Sacedón, Rosa, Vicente, Angeles, Varas, Alberto
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container_end_page 678
container_issue 7
container_start_page 673
container_title Immunology and cell biology
container_volume 93
creator Martínez, Víctor G
Canseco, Noelia M
Hidalgo, Laura
Valencia, Jaris
Entrena, Ana
Fernández‐Sevilla, Lidia M
Hernández‐López, Carmen
Sacedón, Rosa
Vicente, Angeles
Varas, Alberto
description Human thymus contains two major subpopulations of dendritic cells (DCs), conventional DCs (cDCs) and plasmacytoid DCs (pDCs), which are mainly involved in central tolerance and also in protecting the thymus against infections. In blood and peripheral organs cDCs include the subpopulation of BDCA3 hi DCs, considered as equivalents to mouse CD8α + DCs. In this study we describe in human thymus the presence of a discrete population of BDCA3 hi DCs that, like their peripheral counterparts, express CD13, low‐intermediate levels of CD11c, CLEC9A, high levels of XCR1, IRF8 and TLR3, and mostly lack the expression of CD11b, CD14 and TLR7. Thymic BDCA3 hi DCs display immature features with a low expression of costimulatory molecules and HLA‐DR, and a low allostimulatory capacity. Also, BDCA3 hi DCs exhibit a strong response to TLR3 stimulation, producing high levels of interferon (IFN)‐λ1 and CXCL10, which indicates that, similarly to thymic pDCs, BDCA3 hi DCs can have an important role in thymus protection against viral infections.
doi_str_mv 10.1038/icb.2015.22
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title A discrete population of IFN λ‐expressing BDCA3 hi dendritic cells is present in human thymus
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