The effects of steroids on the human lens epithelium
A study of anterior capsules from cataractous lenses revealed that there are marked abnormalities in epithelial structure associated with cataract. In certain cases a distinctive reticulated pattern was observed in whole mounts of the anterior capsule and of these a higher number than expected were...
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| Veröffentlicht in: | Eye (London) 1987-01, Vol.1 (6), p.722-727 |
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| creator | Jacob, T J C Karim, A K A Thompson, G M |
| description | A study of anterior capsules from cataractous lenses revealed that there are marked abnormalities in epithelial structure associated with cataract. In certain cases a distinctive reticulated pattern was observed in whole mounts of the anterior capsule and of these a higher number than expected were from patients receiving steroid medication. In tissue culture experiments it was found that the presence of steroids in the growth medium (10 µM prednisolone) adversely affected the growth of human lens epithelial cells.
These observations are consistent with the hypothesis that steroid-induced cataracts are the result of effects on anterior lens epithelial cell function. |
| doi_str_mv | 10.1038/eye.1987.115 |
| format | Article |
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These observations are consistent with the hypothesis that steroid-induced cataracts are the result of effects on anterior lens epithelial cell function.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Beclomethasone - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cataract - chemically induced</subject><subject>Cataract - pathology</subject><subject>Cell Count - drug effects</subject><subject>Cells, Cultured</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Epithelial Cells</subject><subject>Epithelium - drug effects</subject><subject>Glucocorticoids - adverse effects</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Lens Capsule, Crystalline - drug effects</subject><subject>Lens, Crystalline - drug effects</subject><subject>Lens, Crystalline - pathology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prednisolone - adverse effects</subject><subject>Prednisolone - pharmacology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Time Factors</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptjz1rwzAQQEVpSdO0W9eCh451ehdZkj2W0C8IdEmhm5DlU-PgjyDZQ_59FRIyddKh97jjMXaPMEfg-TPtaY5FruaI4oJNMVMyFZnILtkUCgHpYrH4uWY3IWwBIlQwYRMeuZLZlGXrDSXkHNkhJL1LwkC-r6s4d8kQ0WZsTZc01IWEdnX8aeqxvWVXzjSB7k7vjH2_va6XH-nq6_1z-bJKLS9wSLlUsoqrJc-pMiXmSimecYIK8pIAuDW8kmAJS1E4qdAZJBSqlFApQTmfsafjXuv7EDw5vfN1a_xeI-hDu47t-tCuY3vUH476bixbqs7yKTbyxxM3wZrGedPZOpw1JbiUeLiaHrUQSfdLXm_70Xcx9P-zfypTb-w</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Jacob, T J C</creator><creator>Karim, A K A</creator><creator>Thompson, G M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19870101</creationdate><title>The effects of steroids on the human lens epithelium</title><author>Jacob, T J C ; Karim, A K A ; Thompson, G M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-3676dffe638edab18777343e0d08be003ca3d60ce1b59f671fa1e157b60d75e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Beclomethasone - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cataract - chemically induced</topic><topic>Cataract - pathology</topic><topic>Cell Count - drug effects</topic><topic>Cells, Cultured</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Epithelial Cells</topic><topic>Epithelium - drug effects</topic><topic>Glucocorticoids - adverse effects</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Lens Capsule, Crystalline - drug effects</topic><topic>Lens, Crystalline - drug effects</topic><topic>Lens, Crystalline - pathology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prednisolone - adverse effects</topic><topic>Prednisolone - pharmacology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacob, T J C</creatorcontrib><creatorcontrib>Karim, A K A</creatorcontrib><creatorcontrib>Thompson, G M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, T J C</au><au>Karim, A K A</au><au>Thompson, G M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of steroids on the human lens epithelium</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>1</volume><issue>6</issue><spage>722</spage><epage>727</epage><pages>722-727</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>A study of anterior capsules from cataractous lenses revealed that there are marked abnormalities in epithelial structure associated with cataract. In certain cases a distinctive reticulated pattern was observed in whole mounts of the anterior capsule and of these a higher number than expected were from patients receiving steroid medication. In tissue culture experiments it was found that the presence of steroids in the growth medium (10 µM prednisolone) adversely affected the growth of human lens epithelial cells.
These observations are consistent with the hypothesis that steroid-induced cataracts are the result of effects on anterior lens epithelial cell function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>3454764</pmid><doi>10.1038/eye.1987.115</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 1987-01, Vol.1 (6), p.722-727 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_eye_1987_115 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Beclomethasone - adverse effects Biological and medical sciences Cataract - chemically induced Cataract - pathology Cell Count - drug effects Cells, Cultured Drug toxicity and drugs side effects treatment Epithelial Cells Epithelium - drug effects Glucocorticoids - adverse effects Humans Laboratory Medicine Lens Capsule, Crystalline - drug effects Lens, Crystalline - drug effects Lens, Crystalline - pathology Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Ophthalmology Pharmaceutical Sciences/Technology Pharmacology. Drug treatments Prednisolone - adverse effects Prednisolone - pharmacology Surgery Surgical Oncology Time Factors |
| title | The effects of steroids on the human lens epithelium |
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