Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects
This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin...
Gespeichert in:
| Veröffentlicht in: | Clinical pharmacology and therapeutics 2014-04, Vol.95 (4), p.432-438 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 438 |
|---|---|
| container_issue | 4 |
| container_start_page | 432 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 95 |
| creator | Misaka, S Yatabe, J Müller, F Takano, K Kawabe, K Glaeser, H Yatabe, M S Onoue, S Werba, J P Watanabe, H Yamada, S Fromm, M F Kimura, J |
| description | This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC0–48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [3H]‐Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = 84.3 μmol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2‐mediated nadolol uptake (half‐maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2‐mediated uptake of nadolol in the intestine.
Clinical Pharmacology & Therapeutics (2014); 95 4, 432–438. doi:10.1038/clpt.2013.241 |
| doi_str_mv | 10.1038/clpt.2013.241 |
| format | Article |
| fullrecord | <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1038_clpt_2013_241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_WNG_FPP6HHCD_X</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4771-229e8b98b97e23be13aa0555d35a0808f60bac30345feae87e5c9267463fe0453</originalsourceid><addsrcrecordid>eNp9kEtr20AQgJfSEDtpjr2WvfQoZx_ah45FbeyASUXqEN-W0XrUKl1LRivT-N9Hwk5yKwwMM3zz4CPkM2czzqS99mHXzwTjciZS_oFMuZIi0Uqqj2TKGMuSTEg9IRcxPg1lmll7TiYiTXmmtJiS9bxDbOgKgd42vzH2ddvQoQd9ONB73Ow9RloEiFugedt4bPoORijStqJ3sGlDG2jd0AVC6P8c6K99-YS-j5_IWQUh4tUpX5KHmx-rfJEsf85v82_LxKfG8ESIDG2ZDWFQyBK5BGBKqY1UwCyzlWYleMlkqioEtAaVz4Q2qZYVslTJS5Ic9_qujbHDyu26egvdwXHmRkNuNORGQ24wNPBfjvxuX25x80a_KhmArycAoodQddD4Or5zVmpmjB247Mj9qwMe_n_V5cUqXxarsT4-cXq6jj0-v81C99dpI41yj3dzd1MUerHIv7u1fAGB1o9K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Misaka, S ; Yatabe, J ; Müller, F ; Takano, K ; Kawabe, K ; Glaeser, H ; Yatabe, M S ; Onoue, S ; Werba, J P ; Watanabe, H ; Yamada, S ; Fromm, M F ; Kimura, J</creator><creatorcontrib>Misaka, S ; Yatabe, J ; Müller, F ; Takano, K ; Kawabe, K ; Glaeser, H ; Yatabe, M S ; Onoue, S ; Werba, J P ; Watanabe, H ; Yamada, S ; Fromm, M F ; Kimura, J</creatorcontrib><description>This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC0–48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [3H]‐Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = 84.3 μmol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2‐mediated nadolol uptake (half‐maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2‐mediated uptake of nadolol in the intestine.
Clinical Pharmacology & Therapeutics (2014); 95 4, 432–438. doi:10.1038/clpt.2013.241</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1038/clpt.2013.241</identifier><identifier>PMID: 24419562</identifier><identifier>CODEN: CLPTAT</identifier><language>eng</language><publisher>Basingstoke: Blackwell Publishing Ltd</publisher><subject>Adrenergic beta-Antagonists - pharmacokinetics ; Adrenergic beta-Antagonists - pharmacology ; Adult ; Area Under Curve ; Biological and medical sciences ; Blood Pressure - drug effects ; Catechin - pharmacokinetics ; Cross-Over Studies ; Female ; Food-Drug Interactions ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Intestines - metabolism ; Male ; Medical sciences ; Nadolol - pharmacokinetics ; Nadolol - pharmacology ; Organic Anion Transporters - metabolism ; Pharmacology. Drug treatments ; Tea - chemistry ; Young Adult</subject><ispartof>Clinical pharmacology and therapeutics, 2014-04, Vol.95 (4), p.432-438</ispartof><rights>2014 American Society for Clinical Pharmacology and Therapeutics</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4771-229e8b98b97e23be13aa0555d35a0808f60bac30345feae87e5c9267463fe0453</citedby><cites>FETCH-LOGICAL-c4771-229e8b98b97e23be13aa0555d35a0808f60bac30345feae87e5c9267463fe0453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Fclpt.2013.241$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Fclpt.2013.241$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28360778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24419562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misaka, S</creatorcontrib><creatorcontrib>Yatabe, J</creatorcontrib><creatorcontrib>Müller, F</creatorcontrib><creatorcontrib>Takano, K</creatorcontrib><creatorcontrib>Kawabe, K</creatorcontrib><creatorcontrib>Glaeser, H</creatorcontrib><creatorcontrib>Yatabe, M S</creatorcontrib><creatorcontrib>Onoue, S</creatorcontrib><creatorcontrib>Werba, J P</creatorcontrib><creatorcontrib>Watanabe, H</creatorcontrib><creatorcontrib>Yamada, S</creatorcontrib><creatorcontrib>Fromm, M F</creatorcontrib><creatorcontrib>Kimura, J</creatorcontrib><title>Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects</title><title>Clinical pharmacology and therapeutics</title><addtitle>Clinical Pharmacology & Therapeutics</addtitle><description>This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC0–48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [3H]‐Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = 84.3 μmol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2‐mediated nadolol uptake (half‐maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2‐mediated uptake of nadolol in the intestine.
Clinical Pharmacology & Therapeutics (2014); 95 4, 432–438. doi:10.1038/clpt.2013.241</description><subject>Adrenergic beta-Antagonists - pharmacokinetics</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Catechin - pharmacokinetics</subject><subject>Cross-Over Studies</subject><subject>Female</subject><subject>Food-Drug Interactions</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Intestines - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nadolol - pharmacokinetics</subject><subject>Nadolol - pharmacology</subject><subject>Organic Anion Transporters - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Tea - chemistry</subject><subject>Young Adult</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr20AQgJfSEDtpjr2WvfQoZx_ah45FbeyASUXqEN-W0XrUKl1LRivT-N9Hwk5yKwwMM3zz4CPkM2czzqS99mHXzwTjciZS_oFMuZIi0Uqqj2TKGMuSTEg9IRcxPg1lmll7TiYiTXmmtJiS9bxDbOgKgd42vzH2ddvQoQd9ONB73Ow9RloEiFugedt4bPoORijStqJ3sGlDG2jd0AVC6P8c6K99-YS-j5_IWQUh4tUpX5KHmx-rfJEsf85v82_LxKfG8ESIDG2ZDWFQyBK5BGBKqY1UwCyzlWYleMlkqioEtAaVz4Q2qZYVslTJS5Ic9_qujbHDyu26egvdwXHmRkNuNORGQ24wNPBfjvxuX25x80a_KhmArycAoodQddD4Or5zVmpmjB247Mj9qwMe_n_V5cUqXxarsT4-cXq6jj0-v81C99dpI41yj3dzd1MUerHIv7u1fAGB1o9K</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Misaka, S</creator><creator>Yatabe, J</creator><creator>Müller, F</creator><creator>Takano, K</creator><creator>Kawabe, K</creator><creator>Glaeser, H</creator><creator>Yatabe, M S</creator><creator>Onoue, S</creator><creator>Werba, J P</creator><creator>Watanabe, H</creator><creator>Yamada, S</creator><creator>Fromm, M F</creator><creator>Kimura, J</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201404</creationdate><title>Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects</title><author>Misaka, S ; Yatabe, J ; Müller, F ; Takano, K ; Kawabe, K ; Glaeser, H ; Yatabe, M S ; Onoue, S ; Werba, J P ; Watanabe, H ; Yamada, S ; Fromm, M F ; Kimura, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4771-229e8b98b97e23be13aa0555d35a0808f60bac30345feae87e5c9267463fe0453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adrenergic beta-Antagonists - pharmacokinetics</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Catechin - pharmacokinetics</topic><topic>Cross-Over Studies</topic><topic>Female</topic><topic>Food-Drug Interactions</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Intestines - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nadolol - pharmacokinetics</topic><topic>Nadolol - pharmacology</topic><topic>Organic Anion Transporters - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Tea - chemistry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misaka, S</creatorcontrib><creatorcontrib>Yatabe, J</creatorcontrib><creatorcontrib>Müller, F</creatorcontrib><creatorcontrib>Takano, K</creatorcontrib><creatorcontrib>Kawabe, K</creatorcontrib><creatorcontrib>Glaeser, H</creatorcontrib><creatorcontrib>Yatabe, M S</creatorcontrib><creatorcontrib>Onoue, S</creatorcontrib><creatorcontrib>Werba, J P</creatorcontrib><creatorcontrib>Watanabe, H</creatorcontrib><creatorcontrib>Yamada, S</creatorcontrib><creatorcontrib>Fromm, M F</creatorcontrib><creatorcontrib>Kimura, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misaka, S</au><au>Yatabe, J</au><au>Müller, F</au><au>Takano, K</au><au>Kawabe, K</au><au>Glaeser, H</au><au>Yatabe, M S</au><au>Onoue, S</au><au>Werba, J P</au><au>Watanabe, H</au><au>Yamada, S</au><au>Fromm, M F</au><au>Kimura, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clinical Pharmacology & Therapeutics</addtitle><date>2014-04</date><risdate>2014</risdate><volume>95</volume><issue>4</issue><spage>432</spage><epage>438</epage><pages>432-438</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><coden>CLPTAT</coden><abstract>This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC0–48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [3H]‐Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion–transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = 84.3 μmol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2‐mediated nadolol uptake (half‐maximal inhibitory concentration, IC50 = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2‐mediated uptake of nadolol in the intestine.
Clinical Pharmacology & Therapeutics (2014); 95 4, 432–438. doi:10.1038/clpt.2013.241</abstract><cop>Basingstoke</cop><pub>Blackwell Publishing Ltd</pub><pmid>24419562</pmid><doi>10.1038/clpt.2013.241</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9236 |
| ispartof | Clinical pharmacology and therapeutics, 2014-04, Vol.95 (4), p.432-438 |
| issn | 0009-9236 1532-6535 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_clpt_2013_241 |
| source | MEDLINE; Wiley Online Library |
| subjects | Adrenergic beta-Antagonists - pharmacokinetics Adrenergic beta-Antagonists - pharmacology Adult Area Under Curve Biological and medical sciences Blood Pressure - drug effects Catechin - pharmacokinetics Cross-Over Studies Female Food-Drug Interactions HEK293 Cells Humans Inhibitory Concentration 50 Intestines - metabolism Male Medical sciences Nadolol - pharmacokinetics Nadolol - pharmacology Organic Anion Transporters - metabolism Pharmacology. Drug treatments Tea - chemistry Young Adult |
| title | Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T07%3A49%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Green%20Tea%20Ingestion%20Greatly%20Reduces%20Plasma%20Concentrations%20of%20Nadolol%20in%20Healthy%20Subjects&rft.jtitle=Clinical%20pharmacology%20and%20therapeutics&rft.au=Misaka,%20S&rft.date=2014-04&rft.volume=95&rft.issue=4&rft.spage=432&rft.epage=438&rft.pages=432-438&rft.issn=0009-9236&rft.eissn=1532-6535&rft.coden=CLPTAT&rft_id=info:doi/10.1038/clpt.2013.241&rft_dat=%3Cistex_cross%3Eark_67375_WNG_FPP6HHCD_X%3C/istex_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24419562&rfr_iscdi=true |