Serum microRNA Biomarkers for Drug-Induced Liver Injury

New biomarkers of drug‐induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver‐enriched microRNAs are promising serum biomarkers of acetaminophen‐induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute D...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical pharmacology and therapeutics 2012-09, Vol.92 (3), p.291-293
Hauptverfasser:	Starkey Lewis, P J, Merz, M, Couttet, P, Grenet, O, Dear, J, Antoine, D J, Goldring, C, Park, B K, Moggs, J G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Drug-Related Side Effects and Adverse Reactions Humans Liver - drug effects Medical sciences Mice MicroRNAs - blood Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	New biomarkers of drug‐induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver‐enriched microRNAs are promising serum biomarkers of acetaminophen‐induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute DILI is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes in acetaminophen toxicity, mechanisms of cellular microRNA release, and their potential advantages over current clinical biomarkers of DILI. Clinical Pharmacology & Therapeutics (2012); 92 3, 291–293. doi:10.1038/clpt.2012.101
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2012.101