Targeting MicroRNAs With Small Molecules: From Dream to Reality
Currently, one out of four deaths in the United States is due to cancer; therefore, every major therapeutic advance in cancer has the potential to save many lives. One of the most fascinating discoveries in the area of molecular oncology in the past decade is that, in cancer, alterations in both pro...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2010-06, Vol.87 (6), p.754-758 |
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| creator | Zhang, S Chen, L Jung, E J Calin, G A |
| description | Currently, one out of four deaths in the United States is due to cancer; therefore, every major therapeutic advance in cancer has the potential to save many lives. One of the most fascinating discoveries in the area of molecular oncology in the past decade is that, in cancer, alterations in both protein‐coding genes and noncoding RNAs, known as microRNAs (miRNAs), complement each other. In this article, we focus on a novel idea involving the use of small molecules to target overexpressed miRNAs as a new therapy for diseases, particularly cancer, in humans.
Clinical Pharmacology & Therapeutics (2010) 87 6, 754–758. doi: 10.1038/clpt.2010.46 |
| doi_str_mv | 10.1038/clpt.2010.46 |
| format | Article |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Animals Antineoplastic Agents - pharmacology Biological and medical sciences Drug Delivery Systems Drug Design Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism Neoplasms - drug therapy Neoplasms - epidemiology Neoplasms - genetics Pharmacology. Drug treatments United States - epidemiology |
| title | Targeting MicroRNAs With Small Molecules: From Dream to Reality |
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