Safety Issues of Maternal Drug Therapy During Breastfeeding
Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case–control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in co...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2009-01, Vol.85 (1), p.20-22 |
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| creator | Berlin, CM Paul, IM Vesell, ES |
| description | Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case–control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose–response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.
Clinical Pharmacology & Therapeutics (2009); 85, 1, 20–22 doi:10.1038/clpt.2008.209 |
| doi_str_mv | 10.1038/clpt.2008.209 |
| format | Article |
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Clinical Pharmacology & Therapeutics (2009); 85, 1, 20–22 doi:10.1038/clpt.2008.209</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1038/clpt.2008.209</identifier><identifier>PMID: 19092767</identifier><language>eng</language><publisher>United States</publisher><subject>Analgesics, Opioid - adverse effects ; Analgesics, Opioid - metabolism ; Breast Feeding - adverse effects ; Codeine - adverse effects ; Codeine - metabolism ; Counseling ; Female ; Humans ; Infant ; Infant, Newborn ; Milk, Human - chemistry ; Opioid-Related Disorders - etiology ; Opioid-Related Disorders - genetics ; Opioid-Related Disorders - metabolism ; Pharmacogenetics</subject><ispartof>Clinical pharmacology and therapeutics, 2009-01, Vol.85 (1), p.20-22</ispartof><rights>2009 American Society for Clinical Pharmacology and Therapeutics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3669-47f396163057f11b0a07f7d2845ba0b863d552db1f999bb251a3695d463ef9073</citedby><cites>FETCH-LOGICAL-c3669-47f396163057f11b0a07f7d2845ba0b863d552db1f999bb251a3695d463ef9073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Fclpt.2008.209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Fclpt.2008.209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19092767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlin, CM</creatorcontrib><creatorcontrib>Paul, IM</creatorcontrib><creatorcontrib>Vesell, ES</creatorcontrib><title>Safety Issues of Maternal Drug Therapy During Breastfeeding</title><title>Clinical pharmacology and therapeutics</title><addtitle>Clin Pharmacol Ther</addtitle><description>Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case–control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose–response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.
Clinical Pharmacology & Therapeutics (2009); 85, 1, 20–22 doi:10.1038/clpt.2008.209</description><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - metabolism</subject><subject>Breast Feeding - adverse effects</subject><subject>Codeine - adverse effects</subject><subject>Codeine - metabolism</subject><subject>Counseling</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Milk, Human - chemistry</subject><subject>Opioid-Related Disorders - etiology</subject><subject>Opioid-Related Disorders - genetics</subject><subject>Opioid-Related Disorders - metabolism</subject><subject>Pharmacogenetics</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk4vvZX8gc6TpEl78Eo7PwYTB9brkqzJnHRbSVpG_70tG3jnzXt44eGF8xByy2DKQKT3q6puphwg7QPPyJhJwSMlhTwnYwDACLlQI3IVwk9fY0zTSzJiCMgTlYzJw6d2tunoPITWBrp39F031u90RWe-XdP823pdd3TW-s1uTZ-81aFx1pZ9uyYXTlfB3pzuhHy9POfZW7T4eJ1nj4toJZTCKE6cQMWUAJk4xgxoSFxS8jSWRoNJlSil5KVhDhGN4ZJpoVCWsRLWISRiQqLj7srvQ_DWFbXfbLXvCgbFIKEYJBSDhD6w5--OfN2arS3_6NPXPYBH4LCpbPf_WpEt82yxzIc-jP8Cm7loWA</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Berlin, CM</creator><creator>Paul, IM</creator><creator>Vesell, ES</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200901</creationdate><title>Safety Issues of Maternal Drug Therapy During Breastfeeding</title><author>Berlin, CM ; Paul, IM ; Vesell, ES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3669-47f396163057f11b0a07f7d2845ba0b863d552db1f999bb251a3695d463ef9073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analgesics, Opioid - adverse effects</topic><topic>Analgesics, Opioid - metabolism</topic><topic>Breast Feeding - adverse effects</topic><topic>Codeine - adverse effects</topic><topic>Codeine - metabolism</topic><topic>Counseling</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Milk, Human - chemistry</topic><topic>Opioid-Related Disorders - etiology</topic><topic>Opioid-Related Disorders - genetics</topic><topic>Opioid-Related Disorders - metabolism</topic><topic>Pharmacogenetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlin, CM</creatorcontrib><creatorcontrib>Paul, IM</creatorcontrib><creatorcontrib>Vesell, ES</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlin, CM</au><au>Paul, IM</au><au>Vesell, ES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety Issues of Maternal Drug Therapy During Breastfeeding</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2009-01</date><risdate>2009</risdate><volume>85</volume><issue>1</issue><spage>20</spage><epage>22</epage><pages>20-22</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case–control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose–response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.
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| ispartof | Clinical pharmacology and therapeutics, 2009-01, Vol.85 (1), p.20-22 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Analgesics, Opioid - adverse effects Analgesics, Opioid - metabolism Breast Feeding - adverse effects Codeine - adverse effects Codeine - metabolism Counseling Female Humans Infant Infant, Newborn Milk, Human - chemistry Opioid-Related Disorders - etiology Opioid-Related Disorders - genetics Opioid-Related Disorders - metabolism Pharmacogenetics |
| title | Safety Issues of Maternal Drug Therapy During Breastfeeding |
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