A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia
The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated bcr 1 . The c- abl protooncogene is translocated from chromosome 9 band q34 into bcr and the biochemical consequence of this molecular rearran...
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| Veröffentlicht in: | Nature (London) 1987-02, Vol.325 (6105), p.635-637 |
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| creator | Chan, L. C Karhi, K. K Rayter, S. I Heisterkamp, N Eridani, S Powle, R Lawler, S. D Groffen, J Foulkes, J. G Greaves, M. F Wiedemann, L. M |
| description | The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated
bcr
1
. The c-
abl
protooncogene is translocated from chromosome 9 band q34 into
bcr
and the biochemical consequence of this molecular rearrangement is the production of an abnormal fusion protein
bcr–abl
p210 with enhanced protein-tyrosine kinase activity
2,3
compared to the normal p145 c-
abl
protein. The Ph chromosome translocation is also seen in some acute lymphoblastic leukaemias with B-cell precursor phenotypes
4,5
some of which have
bcr
rearrangement (bcr
+
) and some do not (bcr
-
)
6,7
. We present evidence that the Ph
+
, bcr
-
leukaemias are associated with a novel p190
abl
kinase. We propose that acute lymphoblastic leukaemias that are bcr
+
, p210
+
are probably lymphoid blast crises following a clinically silent chronic phase of chronic myelocytic leukaemia arising in multipotential stem cells whereas bcr
-
p190
+
cases are
de novo
acute lymphoblastic leukaemias arising in more restricted precursors. |
| doi_str_mv | 10.1038/325635a0 |
| format | Article |
| fullrecord | <record><control><sourceid>nature_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1038_325635a0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>325635a0</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1970-5465eada7f624e9c399c54a13539652ac9834c38a3d1891a5cfc60df344807043</originalsourceid><addsrcrecordid>eNqN0E1Lw0AQBuBFFKxV8BfIHvUQ3c1-ZHMsxS8o6EHPYbqZ2NRNNuwmxf4Bf7eRak8ePA0Dz7wMLyHnnF1zJsyNSJUWCtgBmXCZ6URqkx2SCWOpSZgR-picxLhmjCmeyQn5nNHWb9BRWDraBd9j3VL86ALGiCUdl-dV7aBE161qoHYVfOOjb5B2PtZ9vUEKduiRum3TrfzSQexrSx0O74DNePE_dkqOKnARz37mlLze3b7MH5LF0_3jfLZILM8zliipFUIJWaVTibkVeW6VBC6UyLVKweZGSCsMiJKbnIOyldWsrISUhmVMiim53OXa4GMMWBVdqBsI24Kz4ru_4re_kV7taBxJ-4ahWPshtON3f9mLnW2hHwLuQ_fgC7krfNc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia</title><source>SpringerLink Journals</source><source>Nature</source><creator>Chan, L. C ; Karhi, K. K ; Rayter, S. I ; Heisterkamp, N ; Eridani, S ; Powle, R ; Lawler, S. D ; Groffen, J ; Foulkes, J. G ; Greaves, M. F ; Wiedemann, L. M</creator><creatorcontrib>Chan, L. C ; Karhi, K. K ; Rayter, S. I ; Heisterkamp, N ; Eridani, S ; Powle, R ; Lawler, S. D ; Groffen, J ; Foulkes, J. G ; Greaves, M. F ; Wiedemann, L. M</creatorcontrib><description>The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated
bcr
1
. The c-
abl
protooncogene is translocated from chromosome 9 band q34 into
bcr
and the biochemical consequence of this molecular rearrangement is the production of an abnormal fusion protein
bcr–abl
p210 with enhanced protein-tyrosine kinase activity
2,3
compared to the normal p145 c-
abl
protein. The Ph chromosome translocation is also seen in some acute lymphoblastic leukaemias with B-cell precursor phenotypes
4,5
some of which have
bcr
rearrangement (bcr
+
) and some do not (bcr
-
)
6,7
. We present evidence that the Ph
+
, bcr
-
leukaemias are associated with a novel p190
abl
kinase. We propose that acute lymphoblastic leukaemias that are bcr
+
, p210
+
are probably lymphoid blast crises following a clinically silent chronic phase of chronic myelocytic leukaemia arising in multipotential stem cells whereas bcr
-
p190
+
cases are
de novo
acute lymphoblastic leukaemias arising in more restricted precursors.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/325635a0</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Humanities and Social Sciences ; letter ; multidisciplinary ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1987-02, Vol.325 (6105), p.635-637</ispartof><rights>Springer Nature Limited 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1970-5465eada7f624e9c399c54a13539652ac9834c38a3d1891a5cfc60df344807043</citedby><cites>FETCH-LOGICAL-c1970-5465eada7f624e9c399c54a13539652ac9834c38a3d1891a5cfc60df344807043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/325635a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/325635a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Chan, L. C</creatorcontrib><creatorcontrib>Karhi, K. K</creatorcontrib><creatorcontrib>Rayter, S. I</creatorcontrib><creatorcontrib>Heisterkamp, N</creatorcontrib><creatorcontrib>Eridani, S</creatorcontrib><creatorcontrib>Powle, R</creatorcontrib><creatorcontrib>Lawler, S. D</creatorcontrib><creatorcontrib>Groffen, J</creatorcontrib><creatorcontrib>Foulkes, J. G</creatorcontrib><creatorcontrib>Greaves, M. F</creatorcontrib><creatorcontrib>Wiedemann, L. M</creatorcontrib><title>A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated
bcr
1
. The c-
abl
protooncogene is translocated from chromosome 9 band q34 into
bcr
and the biochemical consequence of this molecular rearrangement is the production of an abnormal fusion protein
bcr–abl
p210 with enhanced protein-tyrosine kinase activity
2,3
compared to the normal p145 c-
abl
protein. The Ph chromosome translocation is also seen in some acute lymphoblastic leukaemias with B-cell precursor phenotypes
4,5
some of which have
bcr
rearrangement (bcr
+
) and some do not (bcr
-
)
6,7
. We present evidence that the Ph
+
, bcr
-
leukaemias are associated with a novel p190
abl
kinase. We propose that acute lymphoblastic leukaemias that are bcr
+
, p210
+
are probably lymphoid blast crises following a clinically silent chronic phase of chronic myelocytic leukaemia arising in multipotential stem cells whereas bcr
-
p190
+
cases are
de novo
acute lymphoblastic leukaemias arising in more restricted precursors.</description><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqN0E1Lw0AQBuBFFKxV8BfIHvUQ3c1-ZHMsxS8o6EHPYbqZ2NRNNuwmxf4Bf7eRak8ePA0Dz7wMLyHnnF1zJsyNSJUWCtgBmXCZ6URqkx2SCWOpSZgR-picxLhmjCmeyQn5nNHWb9BRWDraBd9j3VL86ALGiCUdl-dV7aBE161qoHYVfOOjb5B2PtZ9vUEKduiRum3TrfzSQexrSx0O74DNePE_dkqOKnARz37mlLze3b7MH5LF0_3jfLZILM8zliipFUIJWaVTibkVeW6VBC6UyLVKweZGSCsMiJKbnIOyldWsrISUhmVMiim53OXa4GMMWBVdqBsI24Kz4ru_4re_kV7taBxJ-4ahWPshtON3f9mLnW2hHwLuQ_fgC7krfNc</recordid><startdate>19870218</startdate><enddate>19870218</enddate><creator>Chan, L. C</creator><creator>Karhi, K. K</creator><creator>Rayter, S. I</creator><creator>Heisterkamp, N</creator><creator>Eridani, S</creator><creator>Powle, R</creator><creator>Lawler, S. D</creator><creator>Groffen, J</creator><creator>Foulkes, J. G</creator><creator>Greaves, M. F</creator><creator>Wiedemann, L. M</creator><general>Nature Publishing Group UK</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19870218</creationdate><title>A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia</title><author>Chan, L. C ; Karhi, K. K ; Rayter, S. I ; Heisterkamp, N ; Eridani, S ; Powle, R ; Lawler, S. D ; Groffen, J ; Foulkes, J. G ; Greaves, M. F ; Wiedemann, L. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1970-5465eada7f624e9c399c54a13539652ac9834c38a3d1891a5cfc60df344807043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, L. C</creatorcontrib><creatorcontrib>Karhi, K. K</creatorcontrib><creatorcontrib>Rayter, S. I</creatorcontrib><creatorcontrib>Heisterkamp, N</creatorcontrib><creatorcontrib>Eridani, S</creatorcontrib><creatorcontrib>Powle, R</creatorcontrib><creatorcontrib>Lawler, S. D</creatorcontrib><creatorcontrib>Groffen, J</creatorcontrib><creatorcontrib>Foulkes, J. G</creatorcontrib><creatorcontrib>Greaves, M. F</creatorcontrib><creatorcontrib>Wiedemann, L. M</creatorcontrib><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, L. C</au><au>Karhi, K. K</au><au>Rayter, S. I</au><au>Heisterkamp, N</au><au>Eridani, S</au><au>Powle, R</au><au>Lawler, S. D</au><au>Groffen, J</au><au>Foulkes, J. G</au><au>Greaves, M. F</au><au>Wiedemann, L. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><date>1987-02-18</date><risdate>1987</risdate><volume>325</volume><issue>6105</issue><spage>635</spage><epage>637</epage><pages>635-637</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band qll in a 5.8-kilobase (kb) region designated
bcr
1
. The c-
abl
protooncogene is translocated from chromosome 9 band q34 into
bcr
and the biochemical consequence of this molecular rearrangement is the production of an abnormal fusion protein
bcr–abl
p210 with enhanced protein-tyrosine kinase activity
2,3
compared to the normal p145 c-
abl
protein. The Ph chromosome translocation is also seen in some acute lymphoblastic leukaemias with B-cell precursor phenotypes
4,5
some of which have
bcr
rearrangement (bcr
+
) and some do not (bcr
-
)
6,7
. We present evidence that the Ph
+
, bcr
-
leukaemias are associated with a novel p190
abl
kinase. We propose that acute lymphoblastic leukaemias that are bcr
+
, p210
+
are probably lymphoid blast crises following a clinically silent chronic phase of chronic myelocytic leukaemia arising in multipotential stem cells whereas bcr
-
p190
+
cases are
de novo
acute lymphoblastic leukaemias arising in more restricted precursors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/325635a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1987-02, Vol.325 (6105), p.635-637 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_325635a0 |
| source | SpringerLink Journals; Nature |
| subjects | Humanities and Social Sciences letter multidisciplinary Science Science (multidisciplinary) |
| title | A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia |
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