Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

Cell surface 'blebbing' is an early consequence of hypoxic and toxic injury to cells. A rise in cytosolic free Ca2+ has been suggested as the stimulus for bleb formation and the final common pathway to irreversible cell injury. Here, using digitized low-light video microscopy, we examine b...

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Veröffentlicht in:	Nature (London) 1987, Vol.325 (6099), p.78-81
Hauptverfasser:	LEMASTERS, J. J, DIGUISEPPI, J, NIEMINEN, A.-L, HERMAN, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Ageing, cell death Animals Biological and medical sciences Calcium - metabolism Cell physiology Cell Survival Egtazic Acid - pharmacology Epidermal Growth Factor - pharmacology Ethers - pharmacology Fundamental and applied biological sciences. Psychology Hypoxia - pathology Ionomycin Liver - cytology Membrane Potentials Mitochondria, Liver - physiology Molecular and cellular biology Phenylephrine - pharmacology Rats Time Factors Vasopressins - pharmacology
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