Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action

The mouse skin tumour promoter phorbol-12-myristate-13-acetate (PMA) does not form covalent adducts with cellular DNA and its mutagenic potency in several systems is low or absent 1–6 . There have been conflicting reports of the capacity of PMA to produce sister chromatid exchanges (SCEs) 3,6–8 . As...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1981-09, Vol.293 (5828), p.144-146
Hauptverfasser:	Emerit, Ingrid, Cerutti, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chromosome Aberrations Humanities and Social Sciences Humans letter Lymphocyte Activation - drug effects Lymphocytes - drug effects multidisciplinary Phorbols - pharmacology Polyploidy Science Science (multidisciplinary) Sister Chromatid Exchange - drug effects Structure-Activity Relationship Superoxide Dismutase - metabolism Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!