Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut
Secretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as Vibrio cholerae and toxinogenic Escherichia coli . The high incidence of mucosal infections in malnourished protein-deficient children 1 may result from defect...
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| Veröffentlicht in: | Nature (London) 1979-09, Vol.281 (5726), p.64-65 |
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| container_end_page | 65 |
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| container_issue | 5726 |
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| container_title | Nature (London) |
| container_volume | 281 |
| creator | Barry, Wayne S Pierce, Nathaniel F |
| description | Secretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as
Vibrio cholerae
and toxinogenic
Escherichia coli
. The high incidence of mucosal infections in malnourished protein-deficient children
1
may result from defective antibody production
2
, but evidence for this is conflicting
3
. We report here that protein deficiency markedly impairs the mucosal immune response to cholera toxoid/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding. |
| doi_str_mv | 10.1038/281064a0 |
| format | Article |
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Vibrio cholerae
and toxinogenic
Escherichia coli
. The high incidence of mucosal infections in malnourished protein-deficient children
1
may result from defective antibody production
2
, but evidence for this is conflicting
3
. We report here that protein deficiency markedly impairs the mucosal immune response to cholera toxoid/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/281064a0</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Humanities and Social Sciences ; letter ; multidisciplinary ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1979-09, Vol.281 (5726), p.64-65</ispartof><rights>Springer Nature Limited 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-69269f986a5a21a90dda34026853804a61663b9b1d483573fa00f9422f8b78b03</citedby><cites>FETCH-LOGICAL-c282t-69269f986a5a21a90dda34026853804a61663b9b1d483573fa00f9422f8b78b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/281064a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/281064a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Barry, Wayne S</creatorcontrib><creatorcontrib>Pierce, Nathaniel F</creatorcontrib><title>Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Secretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as
Vibrio cholerae
and toxinogenic
Escherichia coli
. The high incidence of mucosal infections in malnourished protein-deficient children
1
may result from defective antibody production
2
, but evidence for this is conflicting
3
. We report here that protein deficiency markedly impairs the mucosal immune response to cholera toxoid/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding.</description><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNptkM1LxDAQxYMouK6Cf4HkqIe6k4-m6VEWv2BBD3ou0zZdu7TJkqSL_vdGVvckDLxh-PGY9wi5ZHDLQOgF1wyURDgiMyYLlUmli2MyA-A6Ay3UKTkLYQMAOSvkjNhX76LpLW3N1vc7jL2ztMEpmEC92Rkf-nowtB-32PvR2EhdR8epcQGHdB0naxIXts4GQ6OjzYcbjMe0frq-XSRJ3mk8Rrqe4jk56XAI5uJX5-T94f5t-ZStXh6fl3errOGax0yVXJVdqRXmyBmW0LYoJHClc6FBomJKibqsWSu1yAvRIUBXSs47XRe6BjEn13vfxrsQvOmqlG5E_1UxqH56qv56SujNHg0JsWvjq42bvE3f_cde7VmLcfLmYHoAvgEDl3L8</recordid><startdate>19790906</startdate><enddate>19790906</enddate><creator>Barry, Wayne S</creator><creator>Pierce, Nathaniel F</creator><general>Nature Publishing Group UK</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19790906</creationdate><title>Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut</title><author>Barry, Wayne S ; Pierce, Nathaniel F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-69269f986a5a21a90dda34026853804a61663b9b1d483573fa00f9422f8b78b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barry, Wayne S</creatorcontrib><creatorcontrib>Pierce, Nathaniel F</creatorcontrib><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barry, Wayne S</au><au>Pierce, Nathaniel F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><date>1979-09-06</date><risdate>1979</risdate><volume>281</volume><issue>5726</issue><spage>64</spage><epage>65</epage><pages>64-65</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Secretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as
Vibrio cholerae
and toxinogenic
Escherichia coli
. The high incidence of mucosal infections in malnourished protein-deficient children
1
may result from defective antibody production
2
, but evidence for this is conflicting
3
. We report here that protein deficiency markedly impairs the mucosal immune response to cholera toxoid/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/281064a0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1979-09, Vol.281 (5726), p.64-65 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_281064a0 |
| source | Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Humanities and Social Sciences letter multidisciplinary Science Science (multidisciplinary) |
| title | Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut |
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