Eight prion strains have PrPSc molecules with different conformations

Variations in prions, which cause different incubation times and deposition patterns of the prion protein isoform called PrP Sc , are often referred to as 'strains'. We report here a highly sensitive, conformation-dependent immunoassay that discriminates PrP Sc molecules among eight differ...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature medicine 1998-10, Vol.4 (10), p.1157-1165
Hauptverfasser:	Safar, Jiri, Wille, Holger, Itri, Vincenza, Groth, Darlene, Serban, Hana, Torchia, Marilyn, Cohen, Fred E., Prusiner, Stanley B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Infectious Diseases Metabolic Diseases Molecular Medicine Neurosciences
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!