Antibody-dependent cell-mediated damage to schistosomula in vitro
ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many in vitro models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts 1–6 . Similar responses could also be involved in protective immunity...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1974-12, Vol.252 (5483), p.503-505 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 505 |
|---|---|
| container_issue | 5483 |
| container_start_page | 503 |
| container_title | Nature (London) |
| container_volume | 252 |
| creator | BUTTERWORTH, A. E STURROCK, R. F HOUBA, V REES, P. H |
| description | ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many
in vitro
models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts
1–6
. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on
Nippostrongylus braziliensis
7
and
Litomosoides carinii
8
in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the
51
Cr-release technique to assay damage to schistosomula of
Schistosoma mansoni in vitro
. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with
S. mansoni
, can damage labelled schistosomula in the absence of added complement. |
| doi_str_mv | 10.1038/252503a0 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1038_252503a0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4431479</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2500-a31abb173743772250896b037d1b51e040b334199ef6d1d4707ac4e4a673e1df3</originalsourceid><addsrcrecordid>eNptkE9LxDAUxIMo67oKfgGlRz1EX5q0aY_L4j9Y8KLnkjSva5c2XZJU2G9vpOuePD1482OYGUKuGTww4MVjmqUZcAUnZM6EzKnIC3lK5gBpQaHg-Tm58H4LABmTYkZmQvDIlXOyXNrQ6sHsqcEdWoM2JDV2He3RtCqgSYzq1QaTMCS-_mp9GPzQj51KWpt8t8ENl-SsUZ3Hq8NdkM_np4_VK12_v7ytlmtax2hAFWdKaya5FFzKNP6KMtfApWE6YwgCNOeClSU2uWFGSJCqFihULjky0_AFuZt8azd477Cpdq7tldtXDKrfEaq_ESJ6M6G7UcceR_DQOur3k-6jYjfoqu0wOhvT_-d1O7FWhdHh0esI_ADVamyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Antibody-dependent cell-mediated damage to schistosomula in vitro</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>BUTTERWORTH, A. E ; STURROCK, R. F ; HOUBA, V ; REES, P. H</creator><creatorcontrib>BUTTERWORTH, A. E ; STURROCK, R. F ; HOUBA, V ; REES, P. H</creatorcontrib><description>ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many
in vitro
models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts
1–6
. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on
Nippostrongylus braziliensis
7
and
Litomosoides carinii
8
in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the
51
Cr-release technique to assay damage to schistosomula of
Schistosoma mansoni in vitro
. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with
S. mansoni
, can damage labelled schistosomula in the absence of added complement.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/252503a0</identifier><identifier>PMID: 4431479</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antibodies ; Chromates ; Chromium Radioisotopes ; Cytotoxicity Tests, Immunologic ; Humanities and Social Sciences ; Humans ; Immunity, Cellular ; letter ; Leukocytes - immunology ; multidisciplinary ; Schistosoma mansoni - immunology ; Schistosomiasis - immunology ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1974-12, Vol.252 (5483), p.503-505</ispartof><rights>Springer Nature Limited 1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2500-a31abb173743772250896b037d1b51e040b334199ef6d1d4707ac4e4a673e1df3</citedby><cites>FETCH-LOGICAL-c2500-a31abb173743772250896b037d1b51e040b334199ef6d1d4707ac4e4a673e1df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/252503a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/252503a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4431479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BUTTERWORTH, A. E</creatorcontrib><creatorcontrib>STURROCK, R. F</creatorcontrib><creatorcontrib>HOUBA, V</creatorcontrib><creatorcontrib>REES, P. H</creatorcontrib><title>Antibody-dependent cell-mediated damage to schistosomula in vitro</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many
in vitro
models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts
1–6
. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on
Nippostrongylus braziliensis
7
and
Litomosoides carinii
8
in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the
51
Cr-release technique to assay damage to schistosomula of
Schistosoma mansoni in vitro
. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with
S. mansoni
, can damage labelled schistosomula in the absence of added complement.</description><subject>Antibodies</subject><subject>Chromates</subject><subject>Chromium Radioisotopes</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>letter</subject><subject>Leukocytes - immunology</subject><subject>multidisciplinary</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis - immunology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE9LxDAUxIMo67oKfgGlRz1EX5q0aY_L4j9Y8KLnkjSva5c2XZJU2G9vpOuePD1482OYGUKuGTww4MVjmqUZcAUnZM6EzKnIC3lK5gBpQaHg-Tm58H4LABmTYkZmQvDIlXOyXNrQ6sHsqcEdWoM2JDV2He3RtCqgSYzq1QaTMCS-_mp9GPzQj51KWpt8t8ENl-SsUZ3Hq8NdkM_np4_VK12_v7ytlmtax2hAFWdKaya5FFzKNP6KMtfApWE6YwgCNOeClSU2uWFGSJCqFihULjky0_AFuZt8azd477Cpdq7tldtXDKrfEaq_ESJ6M6G7UcceR_DQOur3k-6jYjfoqu0wOhvT_-d1O7FWhdHh0esI_ADVamyw</recordid><startdate>19741206</startdate><enddate>19741206</enddate><creator>BUTTERWORTH, A. E</creator><creator>STURROCK, R. F</creator><creator>HOUBA, V</creator><creator>REES, P. H</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19741206</creationdate><title>Antibody-dependent cell-mediated damage to schistosomula in vitro</title><author>BUTTERWORTH, A. E ; STURROCK, R. F ; HOUBA, V ; REES, P. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2500-a31abb173743772250896b037d1b51e040b334199ef6d1d4707ac4e4a673e1df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Antibodies</topic><topic>Chromates</topic><topic>Chromium Radioisotopes</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>letter</topic><topic>Leukocytes - immunology</topic><topic>multidisciplinary</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiasis - immunology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUTTERWORTH, A. E</creatorcontrib><creatorcontrib>STURROCK, R. F</creatorcontrib><creatorcontrib>HOUBA, V</creatorcontrib><creatorcontrib>REES, P. H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUTTERWORTH, A. E</au><au>STURROCK, R. F</au><au>HOUBA, V</au><au>REES, P. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody-dependent cell-mediated damage to schistosomula in vitro</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1974-12-06</date><risdate>1974</risdate><volume>252</volume><issue>5483</issue><spage>503</spage><epage>505</epage><pages>503-505</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>ANTIBODY-DEPENDENT cell-mediated cytotoxic effects have been described in many
in vitro
models involving single-cell suspensions of mammalian or avian target cells, and could be important in the rejection of tumours and allografts
1–6
. Similar responses could also be involved in protective immunity against metazoan parasites, and evidence for cell-mediated effector mechanisms of various types has emerged from work on
Nippostrongylus braziliensis
7
and
Litomosoides carinii
8
in rats. Here we present two new aspects of cell-mediated responses to metazoan parasites. First, we have adapted the
51
Cr-release technique to assay damage to schistosomula of
Schistosoma mansoni in vitro
. Second, we provide evidence that normal human peripheral blood leukocytes, in the presence of sera from patients infected with
S. mansoni
, can damage labelled schistosomula in the absence of added complement.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4431479</pmid><doi>10.1038/252503a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1974-12, Vol.252 (5483), p.503-505 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_crossref_primary_10_1038_252503a0 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Antibodies Chromates Chromium Radioisotopes Cytotoxicity Tests, Immunologic Humanities and Social Sciences Humans Immunity, Cellular letter Leukocytes - immunology multidisciplinary Schistosoma mansoni - immunology Schistosomiasis - immunology Science Science (multidisciplinary) |
| title | Antibody-dependent cell-mediated damage to schistosomula in vitro |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T19%3A56%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antibody-dependent%20cell-mediated%20damage%20to%20schistosomula%20in%20vitro&rft.jtitle=Nature%20(London)&rft.au=BUTTERWORTH,%20A.%20E&rft.date=1974-12-06&rft.volume=252&rft.issue=5483&rft.spage=503&rft.epage=505&rft.pages=503-505&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/252503a0&rft_dat=%3Cpubmed_cross%3E4431479%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/4431479&rfr_iscdi=true |