K+ is an endothelium-derived hyperpolarizing factor in rat arteries

In arteries, muscarinic agonists such as acetylcholine release an unidentified, endothelium-derived hyperpolarizing factor (EDHF) which is neither prostacyclin nor nitric oxide 1 , 2 , 3 . Here we show that EDHF-induced hyperpolarization of smooth muscle and relaxation of small resistance arteries a...

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Veröffentlicht in:	Nature (London) 1998-11, Vol.396 (6708), p.269-272
Hauptverfasser:	Edwards, G., Dora, K. A., Gardener, M. J., Garland, C. J., Weston, A. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Apamin - pharmacology Arteries - drug effects Arteries - physiology Barium - pharmacology Biological and medical sciences Biological Factors - metabolism Biological Factors - physiology Blood vessels and receptors Charybdotoxin - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hepatic Artery Humanities and Social Sciences In Vitro Techniques letter Male Membrane Potentials multidisciplinary Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Ouabain - pharmacology Patch-Clamp Techniques Potassium - metabolism Potassium - physiology Potassium Channel Blockers Potassium Channels - metabolism Rats Rats, Sprague-Dawley Science Science (multidisciplinary) Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism Vasodilation - drug effects Vasodilation - physiology Vertebrates: cardiovascular system
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