Carcinogenicity of Tobacco Smoke Condensate to Mouse Skin

IN his review of the recently published book Tobacco and Tobacco Smoke by Wynder and Hoffmann, Professor Passey 1 draws attention to the discrepancy between results of painting cigarette smoke condensate on the skin of mice in the United States and Great Britain. Results of Wynder et al. 2 , who obt...

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Veröffentlicht in:	Nature (London) 1968-09, Vol.219 (5159), p.1183-1183
Hauptverfasser:	DAVIES, R. F, DAY, T. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogens Humanities and Social Sciences letter Mice multidisciplinary Neoplasms, Experimental - chemically induced Science Science (multidisciplinary) Skin - drug effects Skin Neoplasms - chemically induced Smoking
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description	IN his review of the recently published book Tobacco and Tobacco Smoke by Wynder and Hoffmann, Professor Passey 1 draws attention to the discrepancy between results of painting cigarette smoke condensate on the skin of mice in the United States and Great Britain. Results of Wynder et al. 2 , who obtained in America 44.4 per cent of skin carcinomata from a group of eighty-one mice, are compared with 3–5 per cent obtained by workers in Great Britain. Day's work is quoted in support of these low percentages 3 , and a figure of 3 per cent of 7,875 mice seems to confirm the apparent very low Carcinogenicity. This total, however, includes 1,320 untreated controls and 660 mice treated with the solvent control.
doi_str_mv	10.1038/2191183a0
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subjects	Animals Carcinogens Humanities and Social Sciences letter Mice multidisciplinary Neoplasms, Experimental - chemically induced Science Science (multidisciplinary) Skin - drug effects Skin Neoplasms - chemically induced Smoking
title	Carcinogenicity of Tobacco Smoke Condensate to Mouse Skin
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