Premature Birth in Rats induced by Ethionine Injection
THE injection of pregnant rats with certain antimeta-bolites, such as ethionine, in sub-lethal doses, may result in resorption or stillbirth 1–4 . We wish to report the effect of smaller, repeated doses of ethionine on the course and outcome of pregnancy in rats. Daily subcutaneous injections, in th...
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| Veröffentlicht in: | Nature (London) 1966-06, Vol.210 (5042), p.1271-1271 |
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| container_issue | 5042 |
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| container_title | Nature (London) |
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| creator | CHOW, BACON F. AGUSTIN, CONRADO E. |
| description | THE injection of pregnant rats with certain antimeta-bolites, such as ethionine, in sub-lethal doses, may result in resorption or stillbirth
1–4
. We wish to report the effect of smaller, repeated doses of ethionine on the course and outcome of pregnancy in rats. Daily subcutaneous injections, in the doses listed in Table 1, were given from the twelfth day of pregnancy until delivery. Control animals received saline injections. All injections were in a volume of 1 ml. The date of conception was established by the first appearance of sperm on vaginal smears. |
| doi_str_mv | 10.1038/2101271a0 |
| format | Article |
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1–4
. We wish to report the effect of smaller, repeated doses of ethionine on the course and outcome of pregnancy in rats. Daily subcutaneous injections, in the doses listed in Table 1, were given from the twelfth day of pregnancy until delivery. Control animals received saline injections. All injections were in a volume of 1 ml. The date of conception was established by the first appearance of sperm on vaginal smears.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/2101271a0</identifier><identifier>PMID: 6007807</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Birth Weight ; Ethionine - toxicity ; Female ; Fetal Death ; Fetus - drug effects ; Humanities and Social Sciences ; letter ; multidisciplinary ; Pregnancy ; Pregnancy, Animal ; Rats ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1966-06, Vol.210 (5042), p.1271-1271</ispartof><rights>Springer Nature Limited 1966</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-c78c6d187f83e538201a6c62be2c3cd444bca3a5e62c7d7c90879f9385113f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/2101271a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/2101271a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6007807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHOW, BACON F.</creatorcontrib><creatorcontrib>AGUSTIN, CONRADO E.</creatorcontrib><title>Premature Birth in Rats induced by Ethionine Injection</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE injection of pregnant rats with certain antimeta-bolites, such as ethionine, in sub-lethal doses, may result in resorption or stillbirth
1–4
. We wish to report the effect of smaller, repeated doses of ethionine on the course and outcome of pregnancy in rats. Daily subcutaneous injections, in the doses listed in Table 1, were given from the twelfth day of pregnancy until delivery. Control animals received saline injections. All injections were in a volume of 1 ml. The date of conception was established by the first appearance of sperm on vaginal smears.</description><subject>Animals</subject><subject>Birth Weight</subject><subject>Ethionine - toxicity</subject><subject>Female</subject><subject>Fetal Death</subject><subject>Fetus - drug effects</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><subject>Rats</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptj1FLwzAUhYMoc04f_AFCXxWq9yZpkj7qmDoYKOp7SdPUtdh2JOnD_r2Rjj35dLh8H4d7CLlGuEdg6oEiIJWo4YTMkUuRcqHkKZkDUJWCYuKcXHjfAkCGks_ITABIBXJOxLuznQ6js8lT48I2afrkQwcfsxqNrZJyn6zCthn6prfJum-tCfG4JGe1_vH26pAL8vm8-lq-ppu3l_XycZMahjSkRiojKlSyVsxmTFFALYygpaWGmYpzXhrNdGYFNbKSJgcl8zpnKkNkNVuQ26nVuMF7Z-ti55pOu32BUPwNL47Do3szubux7Gx1NA9LI7-buI-k_7auaIfR9fH5f8p-AZUiXrY</recordid><startdate>19660618</startdate><enddate>19660618</enddate><creator>CHOW, BACON F.</creator><creator>AGUSTIN, CONRADO E.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19660618</creationdate><title>Premature Birth in Rats induced by Ethionine Injection</title><author>CHOW, BACON F. ; AGUSTIN, CONRADO E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-c78c6d187f83e538201a6c62be2c3cd444bca3a5e62c7d7c90879f9385113f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Animals</topic><topic>Birth Weight</topic><topic>Ethionine - toxicity</topic><topic>Female</topic><topic>Fetal Death</topic><topic>Fetus - drug effects</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><topic>Rats</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHOW, BACON F.</creatorcontrib><creatorcontrib>AGUSTIN, CONRADO E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHOW, BACON F.</au><au>AGUSTIN, CONRADO E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premature Birth in Rats induced by Ethionine Injection</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1966-06-18</date><risdate>1966</risdate><volume>210</volume><issue>5042</issue><spage>1271</spage><epage>1271</epage><pages>1271-1271</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE injection of pregnant rats with certain antimeta-bolites, such as ethionine, in sub-lethal doses, may result in resorption or stillbirth
1–4
. We wish to report the effect of smaller, repeated doses of ethionine on the course and outcome of pregnancy in rats. Daily subcutaneous injections, in the doses listed in Table 1, were given from the twelfth day of pregnancy until delivery. Control animals received saline injections. All injections were in a volume of 1 ml. The date of conception was established by the first appearance of sperm on vaginal smears.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6007807</pmid><doi>10.1038/2101271a0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | Animals Birth Weight Ethionine - toxicity Female Fetal Death Fetus - drug effects Humanities and Social Sciences letter multidisciplinary Pregnancy Pregnancy, Animal Rats Science Science (multidisciplinary) |
| title | Premature Birth in Rats induced by Ethionine Injection |
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