Effect of a Dithiol on Survival Time after Irradiation
CONTRARY to previous reports 1 , Doherty et al. 2 obtained partial protection of X-irradiated mice with 2,3-dimercaptopropanol. If a foreign dithiol compound is effective perhaps the dithiol form of an essential metabolite might also prove beneficial in radiation injury. Mice were exposed to 550 r....
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Veröffentlicht in: | Nature 1958-05, Vol.181 (4620), p.1405-1406 |
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description | CONTRARY to previous reports
1
, Doherty
et al.
2
obtained partial protection of X-irradiated mice with 2,3-dimercaptopropanol. If a foreign dithiol compound is effective perhaps the dithiol form of an essential metabolite might also prove beneficial in radiation injury. Mice were exposed to 550 r. acute whole body X-irradiation under our usual conditions
3
. The animals received 50 mgm./kgm. of
DL
-6,8-dithioloctanoic acid, the reduced form of thioctic acid, according to the schedule in Table 1. It is evident that the compound significantly increased the
ST
50 day, particularly if administered prior to irradiation. However, it has no real effect in reducing total mortality. The mechanisms involved in such partial protection are obscure, but dithiols are known to form resonance-stabilized radicals which could interact with the various oxidizing radicals produced by ionizing radiation. Such reactions could be continuous until the dithiol was completely destroyed. If the proportion of dithiol to oxidizeis was in favour of the latter, this could explain the increased
ST
50 day and the unaffected total mortality observed in the group receiving the dithiol immediately prior to irradiation. Pre-irradiation medication could also result in protection of radiosensitive groups in the tissues by direct combination, but it might be difficult to obtain complete coverage. Post-irradiation medication could assist in breaking the chain reaction involving organic peroxides
5
but still not prevent the early damage which would tend to decrease total survival. Thus it would appear that a dithiol can increase survival time, possibly by the above mechanisms, yet give no permanent protection against the lethal effects of ionizing radiation. |
doi_str_mv | 10.1038/1811405b0 |
format | Article |
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1
, Doherty
et al.
2
obtained partial protection of X-irradiated mice with 2,3-dimercaptopropanol. If a foreign dithiol compound is effective perhaps the dithiol form of an essential metabolite might also prove beneficial in radiation injury. Mice were exposed to 550 r. acute whole body X-irradiation under our usual conditions
3
. The animals received 50 mgm./kgm. of
DL
-6,8-dithioloctanoic acid, the reduced form of thioctic acid, according to the schedule in Table 1. It is evident that the compound significantly increased the
ST
50 day, particularly if administered prior to irradiation. However, it has no real effect in reducing total mortality. The mechanisms involved in such partial protection are obscure, but dithiols are known to form resonance-stabilized radicals which could interact with the various oxidizing radicals produced by ionizing radiation. Such reactions could be continuous until the dithiol was completely destroyed. If the proportion of dithiol to oxidizeis was in favour of the latter, this could explain the increased
ST
50 day and the unaffected total mortality observed in the group receiving the dithiol immediately prior to irradiation. Pre-irradiation medication could also result in protection of radiosensitive groups in the tissues by direct combination, but it might be difficult to obtain complete coverage. Post-irradiation medication could assist in breaking the chain reaction involving organic peroxides
5
but still not prevent the early damage which would tend to decrease total survival. Thus it would appear that a dithiol can increase survival time, possibly by the above mechanisms, yet give no permanent protection against the lethal effects of ionizing radiation.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/1811405b0</identifier><identifier>PMID: 13552684</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>BODY ; Caprylates - pharmacology ; CHEMICALS ; Humanities and Social Sciences ; LETHAL DOSE ; letter ; MICE ; multidisciplinary ; RADIATION PROTECTION ; RADIOLOGY AND NUCLEAR MEDICINE ; Science ; Science (multidisciplinary) ; Sulfhydryl Compounds - pharmacology ; SURVIVAL TIME ; Toluene ; X RADIATION</subject><ispartof>Nature, 1958-05, Vol.181 (4620), p.1405-1406</ispartof><rights>Springer Nature Limited 1958</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c329t-69f960e07fefe99eb20969e48c7b480c7254513edd96492abd8a3ee970ad5b313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13552684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4325247$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>HALEY, THOMAS J</creatorcontrib><creatorcontrib>FLESHER, ANNA M</creatorcontrib><creatorcontrib>KOMESU, NATHAN</creatorcontrib><creatorcontrib>Univ. of California, Los Angeles</creatorcontrib><title>Effect of a Dithiol on Survival Time after Irradiation</title><title>Nature</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>CONTRARY to previous reports
1
, Doherty
et al.
2
obtained partial protection of X-irradiated mice with 2,3-dimercaptopropanol. If a foreign dithiol compound is effective perhaps the dithiol form of an essential metabolite might also prove beneficial in radiation injury. Mice were exposed to 550 r. acute whole body X-irradiation under our usual conditions
3
. The animals received 50 mgm./kgm. of
DL
-6,8-dithioloctanoic acid, the reduced form of thioctic acid, according to the schedule in Table 1. It is evident that the compound significantly increased the
ST
50 day, particularly if administered prior to irradiation. However, it has no real effect in reducing total mortality. The mechanisms involved in such partial protection are obscure, but dithiols are known to form resonance-stabilized radicals which could interact with the various oxidizing radicals produced by ionizing radiation. Such reactions could be continuous until the dithiol was completely destroyed. If the proportion of dithiol to oxidizeis was in favour of the latter, this could explain the increased
ST
50 day and the unaffected total mortality observed in the group receiving the dithiol immediately prior to irradiation. Pre-irradiation medication could also result in protection of radiosensitive groups in the tissues by direct combination, but it might be difficult to obtain complete coverage. Post-irradiation medication could assist in breaking the chain reaction involving organic peroxides
5
but still not prevent the early damage which would tend to decrease total survival. Thus it would appear that a dithiol can increase survival time, possibly by the above mechanisms, yet give no permanent protection against the lethal effects of ionizing radiation.</description><subject>BODY</subject><subject>Caprylates - pharmacology</subject><subject>CHEMICALS</subject><subject>Humanities and Social Sciences</subject><subject>LETHAL DOSE</subject><subject>letter</subject><subject>MICE</subject><subject>multidisciplinary</subject><subject>RADIATION PROTECTION</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sulfhydryl Compounds - pharmacology</subject><subject>SURVIVAL TIME</subject><subject>Toluene</subject><subject>X RADIATION</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1958</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1Lw0AQBuBFFFurB_-ALt4UovuV_ThKrVooeLCewyaZtVvabNlNC_57IyntxdMc5uFl5kXompJHSrh-oppSQfKSnKAhFUpmQmp1ioaEMJ0RzeUAXaS0JITkVIlzNKA8z5nUYojkxDmoWhwctvjFtwsfVjg0-HMbd35nV3ju14CtayHiaYy29rb1oblEZ86uElzt5wh9vU7m4_ds9vE2HT_Psooz02bSOCMJEOXAgTFQMmKkAaErVQpNKsVykVMOdW2kMMyWtbYcwChi67zklI_QXZ8bUuuLVPkWqkUVmqa7uRCc5UyoDt33qIohpQiu2ES_tvGnoKT4K6g4FNTZm95utuUa6qPcN9KBhx6kbtV8QyyWYRub7sl_02573Nh2G-GYdhC_wG91qw</recordid><startdate>19580517</startdate><enddate>19580517</enddate><creator>HALEY, THOMAS J</creator><creator>FLESHER, ANNA M</creator><creator>KOMESU, NATHAN</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19580517</creationdate><title>Effect of a Dithiol on Survival Time after Irradiation</title><author>HALEY, THOMAS J ; FLESHER, ANNA M ; KOMESU, NATHAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-69f960e07fefe99eb20969e48c7b480c7254513edd96492abd8a3ee970ad5b313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1958</creationdate><topic>BODY</topic><topic>Caprylates - pharmacology</topic><topic>CHEMICALS</topic><topic>Humanities and Social Sciences</topic><topic>LETHAL DOSE</topic><topic>letter</topic><topic>MICE</topic><topic>multidisciplinary</topic><topic>RADIATION PROTECTION</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sulfhydryl Compounds - pharmacology</topic><topic>SURVIVAL TIME</topic><topic>Toluene</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HALEY, THOMAS J</creatorcontrib><creatorcontrib>FLESHER, ANNA M</creatorcontrib><creatorcontrib>KOMESU, NATHAN</creatorcontrib><creatorcontrib>Univ. of California, Los Angeles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Nature</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HALEY, THOMAS J</au><au>FLESHER, ANNA M</au><au>KOMESU, NATHAN</au><aucorp>Univ. of California, Los Angeles</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a Dithiol on Survival Time after Irradiation</atitle><jtitle>Nature</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1958-05-17</date><risdate>1958</risdate><volume>181</volume><issue>4620</issue><spage>1405</spage><epage>1406</epage><pages>1405-1406</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>CONTRARY to previous reports
1
, Doherty
et al.
2
obtained partial protection of X-irradiated mice with 2,3-dimercaptopropanol. If a foreign dithiol compound is effective perhaps the dithiol form of an essential metabolite might also prove beneficial in radiation injury. Mice were exposed to 550 r. acute whole body X-irradiation under our usual conditions
3
. The animals received 50 mgm./kgm. of
DL
-6,8-dithioloctanoic acid, the reduced form of thioctic acid, according to the schedule in Table 1. It is evident that the compound significantly increased the
ST
50 day, particularly if administered prior to irradiation. However, it has no real effect in reducing total mortality. The mechanisms involved in such partial protection are obscure, but dithiols are known to form resonance-stabilized radicals which could interact with the various oxidizing radicals produced by ionizing radiation. Such reactions could be continuous until the dithiol was completely destroyed. If the proportion of dithiol to oxidizeis was in favour of the latter, this could explain the increased
ST
50 day and the unaffected total mortality observed in the group receiving the dithiol immediately prior to irradiation. Pre-irradiation medication could also result in protection of radiosensitive groups in the tissues by direct combination, but it might be difficult to obtain complete coverage. Post-irradiation medication could assist in breaking the chain reaction involving organic peroxides
5
but still not prevent the early damage which would tend to decrease total survival. Thus it would appear that a dithiol can increase survival time, possibly by the above mechanisms, yet give no permanent protection against the lethal effects of ionizing radiation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13552684</pmid><doi>10.1038/1811405b0</doi><tpages>2</tpages></addata></record> |
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subjects | BODY Caprylates - pharmacology CHEMICALS Humanities and Social Sciences LETHAL DOSE letter MICE multidisciplinary RADIATION PROTECTION RADIOLOGY AND NUCLEAR MEDICINE Science Science (multidisciplinary) Sulfhydryl Compounds - pharmacology SURVIVAL TIME Toluene X RADIATION |
title | Effect of a Dithiol on Survival Time after Irradiation |
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