Genotoxicity of the Hydroquinone Metabolite of Ochratoxin A:  Structure-Activity Relationships for Covalent DNA Adduction

Ochratoxin A (OTA) is a mycotoxin that shows potent nephrotoxicity and renal carcinogenicity in rodents. One hypothesis for OTA-induced tumor formation is based on its genotoxic properties that are promoted by oxidative metabolism. Like other chlorinated phenols, OTA undergoes an oxidative dechlorin...

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Veröffentlicht in:	Chemical research in toxicology 2006-09, Vol.19 (9), p.1241-1247
Hauptverfasser:	Tozlovanu, Mariana, Faucet-Marquis, Virginie, Pfohl-Leszkowicz, Annie, Manderville, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Cell Line DNA Adducts - chemistry Humans Hydroquinones - chemistry Hydroquinones - toxicity Mutagens - pharmacokinetics Mutagens - toxicity Ochratoxins - chemistry Ochratoxins - pharmacokinetics Ochratoxins - toxicity Structure-Activity Relationship
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