Stereospecific Deuterium Substitution Attenuates the Tumorigenicity and Metabolism of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Stereochemical determinants of the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were investigated using the stereospecifically deuterated isotopomers (4R)-[4-2H1]NNK and (4S)-[4-2H1]NNK. Upon ip administration to groups of 20...

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Veröffentlicht in:	Chemical research in toxicology 2003-06, Vol.16 (6), p.794-806
Hauptverfasser:	Jalas, John R, McIntee, Edward J, Kenney, Patrick M. J, Upadhyaya, Pramod, Peterson, Lisa A, Hecht, Stephen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - metabolism Carcinogens - metabolism Carcinogens - toxicity Cytochrome P-450 CYP2A6 Deuterium - chemistry DNA - metabolism DNA Adducts - analysis Dose-Response Relationship, Drug Female Guanine - analogs & derivatives Guanine - metabolism Lung - drug effects Lung - enzymology Lung Neoplasms - chemically induced Lung Neoplasms - pathology Mice Mice, Inbred A Microsomes - enzymology Mixed Function Oxygenases - metabolism Molecular Structure Nitrosamines - chemistry Nitrosamines - metabolism Nitrosamines - toxicity Stereoisomerism Structure-Activity Relationship
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