The Mechanism of Galactosamine Toxicity Revisited; A Metabonomic Study

1H NMR spectroscopy was used to investigate the metabolic effects of the hepatotoxin galactosamine (galN) and the mechanism by which glycine protects against such toxicity. Rats were acclimatized to a 0 or 5% glycine diet for 6 days and subsequently administered vehicle, galN (500 mg/kg), glycine (5...

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Veröffentlicht in:	Journal of proteome research 2007-07, Vol.6 (7), p.2711-2719
Hauptverfasser:	Coen, M, Hong, Y. S, Clayton, T. A, Rohde, C. M, Pearce, J. T, Reily, M. D, Robertson, D. G, Holmes, E, Lindon, J. C, Nicholson, J. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - analysis Animals Diet Galactosamine - antagonists & inhibitors Galactosamine - toxicity Glycine - administration & dosage Glycine - blood Glycine - urine Kupffer Cells - chemistry Kupffer Cells - drug effects Liver - chemistry Liver - drug effects Liver - metabolism Male Nuclear Magnetic Resonance, Biomolecular - methods Rats Rats, Sprague-Dawley Serum - chemistry Uridine - analysis Uridine Diphosphate Galactose - analysis Uridine Diphosphate Glucose - analysis Urine - chemistry
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