Phosphoproteome Profiling of Human Skin Fibroblast Cells in Response to Low- and High-Dose Irradiation

A hallmark of the response to high-dose radiation is the up-regulation and phosphorylation of proteins involved in cell cycle checkpoint control, DNA damage signaling, DNA repair, and apoptosis. Exposure of cells to low doses of radiation has well documented biological effects, but the underlying re...

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Veröffentlicht in:	Journal of proteome research 2006-05, Vol.5 (5), p.1252-1260
Hauptverfasser:	Yang, Feng, Stenoien, David L, Strittmatter, Eric F, Wang, Junhua, Ding, Lianghao, Lipton, Mary S, Monroe, Matthew E, Nicora, Carrie D, Gristenko, Marina A, Tang, Keqi, Fang, Ruihua, Adkins, Joshua N, Camp, David G, Chen, David J, Smith, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Phosphoinositide-Dependent Protein Kinases Amino Acid Motifs Amino Acid Sequence Cells, Cultured Chromatography, Affinity - methods Chromatography, High Pressure Liquid - methods Cyclin-Dependent Kinases - metabolism Cyclin-Dependent Kinases - radiation effects Dose-Response Relationship, Radiation Fibroblasts - metabolism Fibroblasts - radiation effects Humans Mass Spectrometry - methods Molecular Sequence Data Oncogene Protein v-akt - metabolism Oncogene Protein v-akt - radiation effects Phosphoproteins - analysis Phosphoproteins - genetics Phosphoproteins - metabolism Phosphoproteins - radiation effects Phosphorylation Protein Biosynthesis Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - radiation effects Proteomics - methods Signal Transduction - radiation effects Spectrometry, Mass, Electrospray Ionization
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