Proteomic Analysis of Pancreatic Ductal Carcinoma Cells after Combined Treatment with Gemcitabine and Trichostatin A

The human pancreatic adenocarcinoma cell line T3M4 has been treated with two agents, gemcitabine (2‘,2‘-difluorodeoxycytidine, a drug interfering with DNA synthesis) and trichostatin A (a drug interfering with histone acetylation), both separately and in association. The association of the two drugs...

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Veröffentlicht in:	Journal of proteome research 2005-11, Vol.4 (6), p.1909-1916
Hauptverfasser:	Cecconi, Daniela, Donadelli, Massimo, Scarpa, Aldo, Milli, Alberto, Palmieri, Marta, Hamdan, Mahmoud, Areces, Liliana B, Rappsilber, Juri, Righetti, Pier Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Cell Line, Tumor Cell Proliferation Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives DNA - chemistry Dose-Response Relationship, Drug Electrophoresis, Gel, Two-Dimensional Gene Expression Regulation, Neoplastic Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - pharmacology Inhibitory Concentration 50 Mass Spectrometry Peptides - chemistry Protein Binding Protein Synthesis Inhibitors - administration & dosage Proteins - chemistry Proteome Proteomics - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Time Factors
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