Preparation of Grignard Reagents:  FTIR and Calorimetric Investigation for Safe Scale-Up

Preparation of Grignard reagents from organic halides and magnesium pose potential safety hazards on scale-up due to their high exothermic potential which can lead to overpressurization, discharge of contents, or explosion. One of the main challenges arises in ensuring the reaction has initiated bef...

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Veröffentlicht in:	Organic process research & development 1999-09, Vol.3 (5), p.319-329
Hauptverfasser:	am Ende, David J, Clifford, Pamela J, DeAntonis, David M, SantaMaria, Charles, Brenek, Steven J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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