A Synthesis of Atenolol Using a Nitrile Hydration Catalyst

The synthesis of atenolol is described using a platinum containing homogeneous catalyst for the conversion of a nitrile to an amide. The catalytic reaction may be employed as the final step in the synthesis or in the preparation of the intermediate 4-hydroxyphenylacetamide. The structure of the nitr...

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Veröffentlicht in:	Organic process research & development 1998-07, Vol.2 (4), p.274-276
Hauptverfasser:	Akisanya, Joseph, Parkins, Adrian W, Steed, Jonathan W
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Sprache:	eng
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creator	Akisanya, Joseph Parkins, Adrian W Steed, Jonathan W
description	The synthesis of atenolol is described using a platinum containing homogeneous catalyst for the conversion of a nitrile to an amide. The catalytic reaction may be employed as the final step in the synthesis or in the preparation of the intermediate 4-hydroxyphenylacetamide. The structure of the nitrile intermediate, 1-(4‘-cyanomethylphenoxy)-2-hydroxy-3-isopropylaminopropane, has been determined by X-ray crystallography.
doi_str_mv	10.1021/op9800313
format	Article
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title	A Synthesis of Atenolol Using a Nitrile Hydration Catalyst
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