Process Development in the Synthesis of the ACE Intermediate MDL 28,726

MDL 28,726 is a key intermediate in the synthesis of the ACE inhibitors MDL 27,210A and MDL 100,240. An efficient nine-step synthesis of this tricyclic acid, which has three chiral centers, was developed beginning with 3,4-dihydro-2H-pyran. A key step in the synthesis features an enzyme-catalyzed re...

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Veröffentlicht in:	Organic process research & development 1999, Vol.3 (4), p.241-247
Hauptverfasser:	Horgan, Stephen W, Burkhouse, David W, Cregge, Robert J, Freund, David W, LeTourneau, Michael, Margolin, Alexey, Webster, Mark E, Henton, Daniel R, Barton, Kathy P, Clouse, Robert C, DesJardin, Michael A, Donaldson, Richard E, Fetner, Neal J, Goralski, Christian T, Heinrich, Gerald P, Hoops, John F, Keaten, Robert T, McConnell, J. Russell, Nitz, Mark A, Stolz-Dunn, Sandra K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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