Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation

Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of sulfonate esters as potential genotoxic impurities (PGIs). Whilst sulfonate esters could theoretically r...

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Veröffentlicht in:	Organic process research & development 2009-05, Vol.13 (3), p.429-433
Hauptverfasser:	Teasdale, Andrew, Eyley, Stephen C, Delaney, Ed, Jacq, Karine, Taylor-Worth, Karen, Lipczynski, Andrew, Reif, Van, Elder, David P, Facchine, Kevin L, Golec, Simon, Schulte Oestrich, Rolf, Sandra, Pat, David, Frank
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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