Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent, environmentally friendly, practical, and sa...

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Veröffentlicht in:	Organic process research & development 2008-11, Vol.12 (6), p.1146-1155
Hauptverfasser:	Shieh, Wen-Chung, McKenna, Joe, Sclafani, Joseph A, Xue, Song, Girgis, Michael, Vivelo, James, Radetich, Branko, Prasad, Kapa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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