Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant

Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent, environmentally friendly, practical, and sa...

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Veröffentlicht in:Organic process research & development 2008-11, Vol.12 (6), p.1146-1155
Hauptverfasser: Shieh, Wen-Chung, McKenna, Joe, Sclafani, Joseph A, Xue, Song, Girgis, Michael, Vivelo, James, Radetich, Branko, Prasad, Kapa
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container_end_page 1155
container_issue 6
container_start_page 1146
container_title Organic process research & development
container_volume 12
creator Shieh, Wen-Chung
McKenna, Joe
Sclafani, Joseph A
Xue, Song
Girgis, Michael
Vivelo, James
Radetich, Branko
Prasad, Kapa
description We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent, environmentally friendly, practical, and safe and requires no chromatographic purification.
doi_str_mv 10.1021/op800136f
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title Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant
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