Process Development for (S,S)-Reboxetine Succinate via a Sharpless Asymmetric Epoxidation

Reboxetine mesylate is a selective norepinephrine uptake inhibitor (NRI) currently marketed as the racemate. The (S,S)-enantiomer of reboxetine is being evaluated for the treatment of neuropathic pain and a variety of other indications. (S,S)-Reboxetine has usually been prepared by resolution of the...

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Veröffentlicht in:Organic process research & development 2007-05, Vol.11 (3), p.354-358
Hauptverfasser: Henegar, Kevin E, Cebula, Mateusz
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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