Scalable Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B RdRp: Challenges in the Production of a Diastereomeric Mixture

A scalable process is described for the synthesis of 2′-C-methyl­guanosine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)­thio]­ethyl-N-benzyl­phosphor­amidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase. The route features the use of phenyl­boronic acid to transiently protect...

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Veröffentlicht in:Organic process research & development 2015-04, Vol.19 (4), p.520-530
Hauptverfasser: Mayes, Benjamin A, Wang, Jingyang, Arumugasamy, Jeevanandam, Arunachalam, Kannan, Baloglu, Erkan, Bauer, David, Becker, Alan, Chaudhuri, Narayan, Glynn, Roberta, Latham, G. Mark, Li, Jie, Lim, Jinsoo, Liu, Jia, Mathieu, Steve, McGarry, F. Patrick, Rosinovsky, Elodie, Soret, Adrien F, Stewart, Alistair, Moussa, Adel
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Sprache:eng
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