Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate

Herein, the route scouting and early process development of a key cyclopentylpyrimidine ketone intermediate toward the synthesis of Akt inhibitor Ipatasertib are described. Initial supplies of the intermediate were prepared through a method that commenced with the natural product (R)-(+)-pulegone an...

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Veröffentlicht in:	Organic process research & development 2014-12, Vol.18 (12), p.1641-1651
Hauptverfasser:	Lane, Jonathan W, Spencer, Keith L, Shakya, Sagar R, Kallan, Nicholas C, Stengel, Peter J, Remarchuk, Travis
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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