Development of a Total Telescoped Synthesis of a Renin Inhibitor Containing 3,4,5-Substituted Piperidine with Sterically Hindered Amide Bonds

A telescoped synthesis for the manufacturing of a renin inhibitor containing 3,4,5-substituted piperidine with sterically hindered amide bonds via a five-step synthetic route is described. Highlights of this scalable synthesis include: (1) the byproduct-controlled amidation protocol using Ghosez’s r...

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Veröffentlicht in:	Organic process research & development 2014-11, Vol.18 (11), p.1339-1344
Hauptverfasser:	Shieh, Wen-Chung, Du, Zhengming, Kim, Hongyong, Liu, Yugang, Prashad, Mahavir
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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