Commercial Scale Process of Galanthamine Hydrobromide Involving Luche Reduction: Galanthamine Process Involving Regioselective 1,2-Reduction of α,β-Unsaturated Ketone

Effect of lanthanide chloride in the Luche regioselective 1,2-reduction of 1-bromo-11-formyl-nornarwedine (5) was studied. Thus, 1-bromo-11-formyl-nornarwedine (5) is reduced with sodium borohydride in the presence of lanthanide chloride to yield 1-bromo-11-formyl-galanthamine isomers (6), which is...

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Veröffentlicht in:	Organic process research & development 2013-03, Vol.17 (3), p.406-412
Hauptverfasser:	Trinadhachari, Ganala Naga, Kamat, Anand Gopalkrishna, Prabahar, Koilpillai Joseph, Handa, Vijay Kumar, Srinu, Kukunuri Naga Venkata Satya, Babu, Korupolu Raghu, Sanasi, Paul Douglas
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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